1. Anti-infection
  2. Arenavirus

Arenavirus

An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Arenavirus 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-14805
    Tecovirimat 99.88%
    Tecovirimat(ST-246)是口服活性的抗痘病毒化合物,强效选择性对抗多种正痘病毒,EC50值约为10nM。
  • HY-101441
    ST-193 Inhibitor 99.78%
    ST-193是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。
  • HY-101441A
    ST-193 hydrochloride Inhibitor 98.22%
    ST-193 hydrochloride是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。
  • HY-P0323
    GP(33-41) Inhibitor
    GP(33-41) 是一种由 9 个氨基酸残基组成的多肽,它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的最佳序列,能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子,SC50 值为 344 nM。