1. Apoptosis
  2. RIP kinase

RIP kinase

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing interferon β (TRIF) or DNA-dependent activator of interferon regulatory factor (DAI). RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-15760
    Necrostatin-1 Inhibitor 99.20%
    Necrostatin-1是一种有效,选择性和可渗透细胞的坏死性凋亡 (necroptosis) 抑制剂,在Jurkat细胞中的 EC50 为490 nM。它通过抑制坏死性凋亡途径中的死亡域受体激酶RIP (RIP1) 起作用。
  • HY-101872
    GSK'872 Inhibitor 99.65%
    GSK'872 是 RIPK3 抑制剂,高亲和力结合 RIP3 激酶结构域 (IC50=1.8 nM),并抑制激酶活性 (IC50=1.3 nM)。
  • HY-101760
    GSK2982772 Inhibitor >98.0%
    GSK2982772是有效,ATP竞争型的RIP1抑制剂,IC50值为16 nM。
  • HY-100339
    GSK583 Inhibitor 98.07%
    GSK583 是一种高效,高选择性的 RIP2 Kinase 抑制剂,其 IC50 值为 5 nM。
  • HY-18937
    WEHI-345 Inhibitor 98.56%
    WEHI-345是一种有效的选择性RIPK2, IC50为0.13 μM。
  • HY-18900
    Nec-4 Inhibitor
    Nec-4, 一个三环衍生物,是受体相互作用蛋白 1 (RIP1) 的一个有效抑制剂,其 IC50 值为 2.6 μM,Ki 值为 0.46 μM。
  • HY-101032
    RIPA-56 Inhibitor 99.86%
    RIPA-56是一种高效选择和代谢稳定的受体相互作用蛋白1 (RIP1) 抑制剂, 其中IC50值为13nM。
  • HY-19764
    RIP2 kinase inhibitor 1 Inhibitor 98.11%
    RIP2 kinase inhibitor 1 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043446 A1 中的化合物 example 1。
  • HY-19761
    RIP2 kinase inhibitor 2 Inhibitor 99.64%
    RIP2 kinase inhibitor 2 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043437 A1 中的化合物 example 9。
  • HY-100131
    GSK'481 Inhibitor >98.0%
    GSK'481能够在HEK293T细胞中抑制RIP1 WT S166的磷酸化。
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