1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor

TAM Receptor

TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. TAM receptors affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors.

The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. TAM receptor signaling plays an especially important role in the engulfment and phagocytic clearance of apoptotic cells (ACs) and membranes in adult tissues.

TAM Receptor 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-13016
    Cabozantinib Inhibitor 99.92%
    Cabozantinib是一种有效的多受体酪氨酸激酶抑制剂, 抑制VEGFR2c-MetKitAxlFlt3IC50 分别为0.035,1.3,4.6,7 和 11.3 nM。
  • HY-15150
    Bemcentinib Inhibitor 99.76%
    Bemcentinib (R428) 是一种高效的具有选择性的 Axl 抑制剂,IC50 值为 14 nM。
  • HY-12432
    Gilteritinib Inhibitor 99.55%
    Gilteritinib 是一种有效的 FLT3/AXL 抑制剂,IC50 分别为 0.29 nM/0.73 nM。
  • HY-12494
    LDC1267 Inhibitor 99.84%
    LDC1267 是TAM (Tyro3,Axl 和 Mer) 激酶高效选择性抑制剂,对 Tyro3/Axl/Mer IC50值分别为<5 nM/8 nM/29 nM。
  • HY-12076
    BMS 777607 Inhibitor 99.48%
    BMS 777607 是一种 Met-related 抑制剂,能够抑制 c-MetAxlRonTyro3 的活性,IC50 值为 3.9 nM,1.1 nM,1.8 nM 和 4.3 nM。
  • HY-125510
    UNC2541 Inhibitor
    UNC2541 是一种有效 Mer 酪氨酸激酶 (MerTK) 特异性抑制剂,与 MerTK ATP 结合口袋结合,IC50 值为 4.4 nM,对其选择性远高于 Axl,Tyro3 和 Flt3。UNC2541 抑制磷酸化的 MerTK (pMerTK;EC50,510 nM)。
  • HY-100946
    CEP-40783 Inhibitor 98.25%
    CEP-40783是高效选择性,有口服活性的AXLc-Met抑制剂,IC50值分别为7 nM 和12 nM。
  • HY-12963
    Dubermatinib Inhibitor 99.53%
    Dubermatinib (TP-0903) 是具有高效性和选择性的Axl受体酪氨酸激酶抑制剂,IC50值为27 nM。
  • HY-114166
    2-D08 Inhibitor 99.04%
    2-D08是一种有细胞透性的小泛素样修饰蛋白 (sumoylation) 抑制剂。2-D08也可抑制 AxlIC50 为 0.49 nM。
  • HY-15797
    UNC2250 Inhibitor 99.96%
    UNC2250 是一种有效选择性的 Mer 抑制剂,IC50为 1.7 nM,比相关的激酶 Axl 和 Tyro3 选择性高 160 倍和 60 倍。
  • HY-12432A
    Gilteritinib hemifumarate Inhibitor 99.22%
    Gilteritinib hemifumarate 是一种有效的 FLT3/AXL 抑制剂,IC50 分别为 0.29 nM/0.73 nM。
  • HY-12964
    SGI-7079 Inhibitor 99.65%
    SGI-7079是一种Axl抑制剂, 显著抑制 SUM149 和 KPL-4 细胞增殖, IC50 分别为0.43 和 0.16 μM。
  • HY-107145A
    Ningetinib Inhibitor 98.75%
    Ningetinib 是一种有效的口服生物可用的小分子酪氨酸激酶抑制剂 (TKI),对 c-MetVEGFR2AxlIC50 值分别为 6.7, 1.9 和 <1.0 nM。
  • HY-19642A
    Glesatinib hydrochloride Inhibitor 98.25%
    Glesatinib盐酸盐是MET和Axl受体酪氨酸激酶抑制剂。
  • HY-100509
    NPS-1034 Inhibitor >98.0%
    NPS-1034 是 AXLMET 的双重抑制剂,其 IC50 值分别为 10.3 和 48 nM。
  • HY-15798
    UNC2881 Inhibitor 99.92%
    UNC2881是特异的Mer激酶抑制剂,能抑制稳态的Mer激酶磷酸化,IC50为22 nM。
  • HY-107145
    Ningetinib Tosylate Inhibitor 99.88%
    Ningetinib Tosylate 是一种有效的口服生物可用的小分子酪氨酸激酶抑制剂 (TKI),对 c-MetVEGFR-2AxlIC50 值分别为 6.7, 1.9 和 <1.0 nM。
  • HY-104075
    R916562 Inhibitor
    R916562 是有效的和有选择性的 Axl/VEGF-R2 双重抑制剂, IC50 值分别为 136 和 24 nM。
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