1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. UNC2541

UNC2541 

目录号: HY-125510
产品使用指南

UNC2541 是一种有效 Mer 酪氨酸激酶 (MerTK) 特异性抑制剂,与 MerTK ATP 结合口袋结合,IC50 值为 4.4 nM,对其选择性远高于 Axl,Tyro3 和 Flt3。UNC2541 抑制磷酸化的 MerTK (pMerTK;EC50,510 nM)。

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UNC2541 Chemical Structure

UNC2541 Chemical Structure

CAS No. : 1612782-86-1

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Description

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

IC50 & Target

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (21.21 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1206 mL 10.6029 mL 21.2058 mL
5 mM 0.4241 mL 2.1206 mL 4.2412 mL
10 mM 0.2121 mL 1.0603 mL 2.1206 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
References
Molecular Weight

471.57

Formula

C₂₄H₃₄FN₇O₂

CAS No.

1612782-86-1

SMILES

O=C(C(C(NCCCC[C@@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
UNC2541
目录号:
HY-125510
需求量:

UNC2541

Cat. No.: HY-125510