1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品 (97):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine盐酸盐是非选择性毒蕈碱乙酰胆碱受体(mAChR)激动剂。
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine氯化物用来研究nAChR和mAchR的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbamoylcholine是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbamoylcholine是nAChR和mAchR受体激动剂, 针对不同的受体, Ki值为10到10,000 nM。
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.07%
    Atropine硫酸一水合物是毒蕈碱乙酰胆碱受体拮抗剂。
  • HY-A0012
    Darifenacin hydrobromide Antagonist 99.64%
    Darifenacin HBr(UK88525)是选择性M3蕈毒碱受体拮抗剂,pKi为8.9。
  • HY-A0034
    Solifenacin Antagonist 99.56%
    Solifenacin 是一种新型的毒蕈碱受体拮抗剂,对 M1M2M3 受体的 pKi 值分别为 7.6, 6.9 和 8.0。
  • HY-15851
    Revefenacin Antagonist 99.62%
    Revefenacin (TD-4208;GSK1160724) 是有效的mAChR拮抗剂,在M3受体上具有高亲和力,Ki 值为0.18 nM。
  • HY-B2070
    Methylbenactyzium Bromide Inhibitor >98.0%
    Methylbenactyzium Bromide 是一种毒蕈碱性乙酰胆碱受体 (mAChR) 抑制剂。
  • HY-12100
    Umeclidinium bromide Inhibitor 99.72%
    Umeclidinium bromide 是一种 mAChR 拮抗剂。Umeclidinium bromide作用于克隆的人M1-M5 mAChRs,Ki 为 0.05 到 0.16 nM。
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride是选择性毒蕈碱受体mAChR激动剂。
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708)是M1毒蕈碱受体激动剂。
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.92%
    Benzotropine是抗毒蕈碱的化合物,可辅助治疗帕金森病。
  • HY-16171
    Diphenmanil methylsulfate Antagonist 99.60%
    Diphemanil硫酸二甲酯能结合毒蕈碱型乙酰胆碱受体进而降低胃酸,唾液和汗液的分泌排泄。
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol氯化物是毒蕈碱型受体(mAChR)选择性激动剂,而对烟碱受体无活性。
  • HY-13204
    Biperiden Hydrochloride Inhibitor
    Biperiden(KL 373)盐酸盐是M1胆碱受体阻断剂,可作用于帕金森症。
  • HY-B0549A
    Flavoxate hydrochloride Antagonist 99.54%
    Flavoxate(DW-61)盐酸盐是毒蕈碱受体AChR拮抗剂, IC50为12.2 μM。
  • HY-A0016
    Dronedarone Inhibitor 99.62%
    Dronedarone(Multaq)可作用于阵发性和持续性房颤或房扑。
  • HY-B0327
    Irsogladine Inhibitor 99.54%
    Irsogladine是PDE4抑制剂和毒蕈碱乙酰胆碱受体结合剂。
  • HY-14562
    TBPB Agonist 99.92%
    TBPB是M1 mAChR变构激动剂,EC50值为289nM,调节amyloid的加工和小鼠体内具有抗精神病药物等活性。