1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品 (104):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine Hydrochloride 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.62%
    Atropine硫酸一水合物是毒蕈碱乙酰胆碱受体拮抗剂。
  • HY-A0012
    Darifenacin hydrobromide Antagonist
    Darifenacin HBr(UK88525)是选择性M3蕈毒碱受体拮抗剂,pKi为8.9。
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride是选择性毒蕈碱受体mAChR激动剂。
  • HY-B2146
    Scopolamine N-oxide hydrobromide Antagonist >98.0%
    Scopolamine N-oxide hydrobromide 是毒蕈碱乙酰胆碱的拮抗剂。
  • HY-112209
    VU0467154 Agonist 98.78%
    VU0467154 是一种 M4 毒蕈碱的乙酰胆碱受体 (M4 muscarinic acetylcholine receptor (mAChR)) 的正向调节剂,能够增强小鼠,人和食蟹猴 M4 受体对乙酰胆碱的反应,pEC50 值分别为 7.75,6.2 和 6。
  • HY-100154
    Darenzepine Inhibitor
    Darenzepine 是一种毒蕈碱受体抑制剂,来自专利 US 20170095465 A1。
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol氯化物是毒蕈碱型受体(mAChR)选择性激动剂,而对烟碱受体无活性。
  • HY-12100
    Umeclidinium bromide Antagonist 99.72%
    Umeclidinium bromide 是一种 mAChR 拮抗剂。Umeclidinium bromide 作用于克隆的人 M1-M5 mAChRs,Ki 为 0.05 到 0.16 nM。
  • HY-16171
    Diphenmanil methylsulfate Antagonist 99.83%
    Diphemanil硫酸二甲酯能结合毒蕈碱型乙酰胆碱受体进而降低胃酸,唾液和汗液的分泌排泄。
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708)是M1毒蕈碱受体激动剂。
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.92%
    Benzotropine是抗毒蕈碱的化合物,可辅助治疗帕金森病。
  • HY-B0662
    Imidafenacin Inhibitor 98.38%
    Imidafenacin(KRP-197; ONO-8025)是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM,对M2受体Kb值稍弱。
  • HY-15618
    MK-7622 Modulator 99.72%
    M1 receptor modulator 是一种毒蕈碱M1受体正变构调节剂。
  • HY-12980
    Batefenterol Antagonist 98.30%
    Batefenterol (GSK961081;TD-5959)是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂; 对hM2,hM3和β2-肾上腺素受体有高亲和力,Ki值分别为1.4, 1.3和3.7nM。
  • HY-17037
    Pirenzepine dihydrochloride 99.60%
    Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 型毒蕈碱受体拮抗剂。
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium溴化物有抗毒蕈碱活性,可用于解痉。
  • HY-A0016
    Dronedarone Inhibitor 99.62%
    Dronedarone(Multaq)可作用于阵发性和持续性房颤或房扑。
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