1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品 (105):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine Hydrochloride 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine氯化物用来研究nAChR和mAchR的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbamoylcholine是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbamoylcholine是nAChR和mAchR受体激动剂, 针对不同的受体, Ki值为10到10,000 nM。
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.62%
    Atropine硫酸一水合物是毒蕈碱乙酰胆碱受体拮抗剂。
  • HY-A0012
    Darifenacin hydrobromide Antagonist
    Darifenacin HBr(UK88525)是选择性M3蕈毒碱受体拮抗剂,pKi为8.9。
  • HY-107651
    VU 0365114 Modulator 99.41%
    VU 0365114 是 mAChR M5 的正变构调节剂,其EC50 值为2.7 μM。
  • HY-12157
    VU 0238429 Modulator 99.96%
    VU 0238429 是 mAChR M5 的正变构调节剂,其 EC50 值为 1.16 μM。
  • HY-B1205
    Atropine Antagonist 99.55%
    Atropine主要用于治疗一些神经毒剂或农药中毒、心率减缓等症状,以及在外科手术中减少唾液的产生。
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。
  • HY-12100
    Umeclidinium bromide Antagonist 99.72%
    Umeclidinium bromide 是一种 mAChR 拮抗剂。Umeclidinium bromide 作用于克隆的人 M1-M5 mAChRs,Ki 为 0.05 到 0.16 nM。
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride是选择性毒蕈碱受体mAChR激动剂。
  • HY-17037
    Pirenzepine dihydrochloride 99.60%
    Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 型毒蕈碱受体拮抗剂。
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol氯化物是毒蕈碱型受体(mAChR)选择性激动剂,而对烟碱受体无活性。
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.92%
    Benzotropine是抗毒蕈碱的化合物,可辅助治疗帕金森病。
  • HY-13204
    Biperiden Hydrochloride Inhibitor >98.0%
    Biperiden(KL 373)盐酸盐是M1胆碱受体阻断剂,可作用于帕金森症。
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708)是M1毒蕈碱受体激动剂。
  • HY-B0662
    Imidafenacin Inhibitor 98.38%
    Imidafenacin(KRP-197; ONO-8025)是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM,对M2受体Kb值稍弱。
  • HY-12980
    Batefenterol Antagonist 98.30%
    Batefenterol (GSK961081;TD-5959)是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂; 对hM2,hM3和β2-肾上腺素受体有高亲和力,Ki值分别为1.4, 1.3和3.7nM。
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium溴化物有抗毒蕈碱活性,可用于解痉。
  • HY-17360
    Tiotropium Bromide Antagonist 99.61%
    Tiotropium溴化物是 毒蕈碱乙酰胆碱受体(mAChR)拮抗剂,可阻断乙酰胆碱配体的结合。
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