Anti-Human/Rat/Fish AChR Antibody (Mab35) 

Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models^[1][2][3].

Rat IgG1 kappa

Rat IgG1 kappa, Isotype Control

AChR

Anti-Human/Rat/Fish AChR Antibody (Mab35) (10 nM, 24 小时) 显著抑制牛肾上腺嗜铬细胞中儿茶酚胺的分泌^[2]。
Anti-Human/Rat/Fish AChR Antibody (Mab35) 特异性结合 TIB-175 杂交瘤细胞中 nAChR 的 α1, α3,和 α5 亚基^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Rat/Fish AChR Antibody (Mab35) (1 mg/kg, 静脉注射, 在注射 C5 siRNA/LNP 后的第七天) 成功构建了雌性 Lewis 大鼠的重症肌无力 (MG) 模型^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1138  [NCBI]

P30532 / NP_000736.2

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kuboi Y, et al. Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis. Mol Ther Nucleic Acids. 2023 Jan 13;31:339-351.  [Content Brief]

  [2]. Gu H, et al. Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35-nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion. J Neurochem. 1996 Apr;66(4):1454-61.  [Content Brief]

  [3]. Jin L, et al. Nicotinic receptor alpha subunits in magnocellular neurons of rat hypothalamus. Neuroreport. 2004 Oct 25;15(15):2333-6.  [Content Brief]