2. Protein Tyrosine Kinase/RTK Apoptosis
  3. c-Kit Apoptosis
  4. Antitumor agent-70

Antitumor agent-70 (化合物8b) 具有抗肿瘤活性，可以诱导细胞凋亡 (apoptosis)。Antitumor agent-70 抑制多发性骨髓瘤的 IC50 值为0.12 μM。Antitumor agent-70 是一种潜在的多靶点激酶抑制剂，尤其是对 c-Kit。

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Antitumor agent-70 Chemical Structure

Antitumor agent-70 Chemical Structure

CAS No. : 2454133-88-9

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Antitumor agent-70 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].

体外研究
(In Vitro)

Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-70 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC
Concentration: 0-50 μM
Incubation Time: 24 hours
Result: Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC50 value of 3.81 μM, 0.12 μM, 12.09 μM respectively.

Cell Cycle Analysis[1]

Cell Line: RPMI8226
Concentration: 0-0.2 μM
Incubation Time: 24 hours
Result: Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly.

Apoptosis Analysis[1]

Cell Line: RPMI8226
Concentration: 0-0.2 μM
Incubation Time: 24 hours
Result: Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.
分子量

358.39

Formula

C21H18N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-70 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-702454133-88-9Antitumor agent70Antitumor agent 70c-KitApoptosisSCFRCD117AntitumorMultiple myeloma (MM)Kinase inhibitorInhibitorinhibitorinhibit

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