2. GPCR/G Protein Immunology/Inflammation MAPK/ERK Pathway Neuronal Signaling Membrane Transporter/Ion Channel
  3. CCR CXCR p38 MAPK JNK Calcium Channel
  4. Catenarin

Catenarin 是一种蒽醌化合物，可以抑制 CCR5 和 CXCR4 介导的趋化作用。 Catenarin 可减少促分裂原活化蛋白激酶 (p38 和 JNK) 及其上游激酶 (MKK6 和 MKK7) 的磷酸化以及钙动员。Catenarin 具有抗炎作用并且可以在糖尿病中抑制白细胞的迁移。Catenarin 对革兰氏阳性细菌表现出显著的抑制作用。Catenarin 在非肥胖糖尿病小鼠中可预防 1 型糖尿病 (T1D)[1][2]。

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Catenarin Chemical Structure

Catenarin Chemical Structure

CAS No. : 476-46-0

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Catenarin 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

查看 CXCR 亚型特异性产品:

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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JNK1 JNK2 JNK3 JNK

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].

体外研究
(In Vitro)

Catenarin (0-2.5 μg/mL, 1 h) 抑制 JK-EF1α-CCR5 细胞中 CCR5 (IC50 = 0.24 μg/mL) 介导的趋化作用和 Jurkat 细胞中 CXCR4 (IC50 = 0.46 μg/mL) 介导的趋化作用[1]。

Catenarin (1-5 μg/mL, 1 h) 抑制 JK-EF1α-CCR5 细胞和 Jurkat 细胞中 CCR5 和 CXCR4 途径的钙动员[1]。

Catenarin (0.1-0.2 μg/mL, 0-10 h) 抑制 JK-EF1α-CCR5 细胞和 Jurkat 细胞中 CCR5 和 CXCR4 途径的 MAPK 级联激活[1]。

Catenarin (1 μg/mL, 1 h) 不影响 JK-EF1α-CCR5 细胞或 Jurkat 细胞中 CCR5 和 CXCR4 受体的表面表达[1]。

Catenarin (0.1-0.2 μg/mL，0-10小时) 对革兰氏阳性细菌表现出显著的抑制作用，最小抑菌浓度 (MIC) 在复杂培养基中为 1 μg/mL，在合成培养基中为 0.2 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Catenarin 相关抗体:

Cell Migration Assay [1]

Cell Line: Jurkat cells and JK-EF1α-CCR5 cells
Concentration: 0.5 μg/mL
Incubation Time: 8 h
Result: Abolished the movement of Jurkat cells and JK-EF1α-CCR5 cells toward SDF-1β and MIP-1β.
Abolished Jurkat cell migration mediated by MKK6 and MKK7.

Western Blot Analysis[1]

Cell Line: Jurkat cells, JK-EF1α-CCR5 cells and JK-EF1α-CCR5 cells
Concentration: 1 μg/mL
Incubation Time:
Result: Inhibited the phosphorylation of the p38 and JNK in JK-EF1α-CCR5 and Jurkat cells in response to MIP-1β and SDF-1β.
Increased the phosphorylation of ERK1/2.
Reduced the phosphorylation of MKK6 in K-EF1α-CCR5 cells triggered by MIP-1β and Jurkat cells triggered by SDF-1β.
Decreased the phosphorylation of MKK7.
体内研究
(In Vivo)

Catenarin (4-40 mg/kg，腹腔注射，每周三次，4-30 周) 可显著抑制 NOD 小鼠的白细胞迁移、胰岛破坏和 1 型糖尿病发生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD mice (4-30 weeks)[1]
Dosage: 0.4, 4, and 20 mg/kg
Administration: i.p. three times per week for 26 weeks
Result: Reduced diabetes in the age-matched mice by 33%, 86%, and 100%.
Prevented T1D in NOD mice to a greater extent than Aspirin (acetylsalicylic acid) (HY-14654).
Showed a marginal-to-modest islet destruction and leukocyte infiltration at 4 mg/kg and over.
Reduced the level of blood glucose and HbA1C at 4 mg/kg and over.
Reduced the number of CD8+ T cells and dendritic cells.
分子量

286.24

Formula

C15H10O6
CAS 号
结构分类
初始来源

Conoideocrella krungchingensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Catenarin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catenarin476-46-0KatenarinCCRCXCRp38 MAPKJNKCalcium ChannelCC chemokine receptorCXC chemokine receptorsC-X-C motif chemokine receptorsc-Jun N-terminal kinaseCa2+ channelsCa channelsCCR5CXCR4type 1 diabetesbacteriaJurkat cellssplenocytesInhibitorinhibitorinhibit

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