2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. CE-355621

CE-355621 是一种人源化的抗 c-Met IgG1 单克隆抗体。CE-355621 在 A549 细胞中能有效地与人 c-Met 结合 (KD = 200 pM, IC50 = 466 pM)，在食蟹猴肾细胞中能与食蟹 c-Met 有效结合 (KD = 610 pM)。CE-355621 通过阻断 HGF 结合来抑制 c-Met 信号通路。CE-355621 显著抑制依赖 c-Met/HGF 途径的肿瘤生长。CE-355621 可用于胶质母细胞瘤和胃癌等癌症的研究。

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CE-355621 Chemical Structure

CE-355621 Chemical Structure

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CE-355621 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. CE-355621 can effectively bind with human c-Met (KD = 200 pM, IC50 = 466 pM) in A549 cells and cyno c-Met (KD = 610 pM) in cynomolgus kidney cells. CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding. CE-355621 significantly inhibit the growth of tumors dependent on the c-Met/HGF pathway. CE-355621 can be used for research on cancer such as glioblastoma and gastric cancer[1][2].

IC50 & Target[1][2]

c-Met

 

体外研究
(In Vitro)

CE-355621 (0.01-100 nM, 4 小时) 可以有效阻断 c-Met 与 HGF 的结合，并诱导 A549 细胞中 c-Met 的降解[1]。
CE-355621 (0.01 nM-10 nM, 24 小时) 显著抑制 U87MG 细胞中 c-Met 的活化[1]。
CE-355621 (0.01-10 μg/mL, 48 小时) 可诱导 U87MG 细胞中 c-Met 的降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CE-355621 相关抗体:

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 0.01 nM-10 nM
Incubation Time: 24 h
Result: Significantly inhibited activation of c-Met.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 0.01-10 μg/mL
Incubation Time: 48 h
Result: Reduced the level of c-Met.
体内研究
(In Vivo)

CE-355621 (25-200 μg, 腹腔注射, 在第0, 2, 3, 6 和 8 天) 显著延迟了U87MG 异种移植瘤雌性 CD-1 nu/nu 小鼠的肿瘤生长[1]。
CE-355621 (400 μg, 腹腔注射, 第 7 天和第 14 天) 显著抑制 GTL-16 异种移植瘤的雌性 CD-1 nu/nu 小鼠的肿瘤生长[1]。
CE-355621 (200 μg, 腹腔注射, 单次剂量, 第 7 天) 可有效抑制 U87MG 异种移植瘤的雌性裸鼠 (nu/nu) 的肿瘤体积生长和 18F-FDG 的摄取[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×106 U87MG cells injected female CD-1 nu/nu mice[1]
Dosage: 25, 100 and 200 μg
Administration: Intraperitoneal injection (i.p.) on day 0, 2, 3, 6 and 8
Result: Significantly delayed tumor growth (up to 22.3 days) and inhibited 80 % of c-Met phosphorylation.
Animal Model: 1.0-5.0×106 GTL-16 cells injected female CD-1 nu/nu mice[1]
Dosage: 400 μg
Administration: Intraperitoneal injection (i.p.) on day 7 and 14
Result: Inhibited tumor growth by 85% and reduced c-Met phosphorylation by 48%
Animal Model: 1×106 U87MG cells injected female nude (nu/nu) mice[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), single dose on day 7
Result: Significantly inhibited tumor volume.
Significantly reduced uptake of 18F-FDG.
基因 ID

4233  [NCBI]

Accession
靶点

HGFR/c-Met
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CE-355621 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CE-355621CE355621CE 355621c-Met/HGFRc-MetHGFU87MGGTL-16antitumorInhibitorinhibitorinhibit

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