2. Anti-infection Immunology/Inflammation NF-κB
  3. Bacterial IFNAR Nuclear Factor of activated T Cells (NFAT) NF-κB
  4. Centaurein

Centaurein 是一种黄酮类化合物并且是 IFN-γ 启动子增强剂。Centaurein 可上调 NFAT 和 NF-κB 增强子的活性。Centaurein 能显著提升 T 细胞 和 NK 细胞中 IFN-γ 的表达水平，并增加小鼠血清中的 IFN-γ 浓度。Centaureidin 可完全松弛大鼠完整主动脉环的收缩。Centaurein 能有效保护小鼠抵御李斯特菌 (Listeria) 感染[1][2][3][4]。

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Centaurein Chemical Structure

Centaurein Chemical Structure

CAS No. : 35595-03-0

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Centaurein 相关抗体

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection[1][2][3][4].

体外研究
(In Vitro)

Centaurein (5-100 μg/mL, 24-72 h) 可刺激 T 细胞系 Jurkat 细胞和脾细胞中 IFN-γ 的转录，并上调 NFAT 和 NF-κB 增强子的活性[1][2][3]。

Centaurein (100 μg/mL, 24 h) 上调 T 细胞中 T-bet 和 IFN-γ 的转录，但对 GATA-3 和 IL-4 无影响[2]。

Centaurein (6 h) 预处理可将巨噬细胞中李斯特菌感染率从 46% 降至 15%，该效应可被 IFN-γ 中和抗体部分逆转 (感染率回升至 34%)[2]。

Centaureidin (10-100 μM) 能以浓度依赖的方式完全松弛 Norepinephrine (NA) (HY-13715) (IC50= 16.7 μM) 或高钾浓度 (IC50= 16.1 μM) 诱导的完整大鼠主动脉环收缩[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Centaurein 相关抗体:

Real Time qPCR[2]

Cell Line: T cells
Concentration: 100 μg/mL
Incubation Time: 24 h
Result: Increased the expression of T-bet by 5-fold.
Enhanced the transcription of IFN-γ but not IL-4 or GATA-3.
体内研究
(In Vivo)

Centaurein (20 μg/只，腹腔注射，单次剂量) 可提升小鼠血清IFN-γ水平，并在注射后 24 小时达到峰值[2]。

Centaurein (20 μg/只，腹腔注射，单次剂量) 通过上调 IFN-γ 和激活巨噬细胞，对小鼠李斯特菌感染具有预防和治疗作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks C57BL/6J mice and IFN-γ−/− C57BL/6J mice[2]
Dosage: 20 μg/mouse
Administration: i.p. for single dose
Result: Protected mice against Listeria infection in a dose-dependent fashion.
Did not protect IFN-γ-knockout mice against Listeria infection, but Ampicillin (HY-B0522) at 1000 μg/mL could protect against Listeria infection.
Rescued 30% of the mice infected with a lethal dose of Listeria (2 × 10 6 CFU).
Rescued 70% of the mice that received the lethal dose of Listeria in combination with antibiotics (5 μg/mouse, 2 times/day for 3 days)
分子量

522.46

Formula

C24H26O13
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Centaurein 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centaurein35595-03-0BacterialIFNARNuclear Factor of activated T Cells (NFAT)NF-κBInterferon-α/β receptorInterferon-alpha/beta receptor Nuclear factor-κBNuclear factor-kappaBBidens pilosaListeriaIFN-γNFATT cellsNK cellsInhibitorinhibitorinhibit

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