2. Apoptosis
  3. Apoptosis
  4. ent-Kaurane-3α,16β,17-triol

ent-Kaurane-3α,16β,17-triol (Compound 3) 是一种抗癌剂。ent-Kaurane-3α,16β,17-triol 诱导 HCT116 细胞凋亡 (apoptosis)。

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ent-Kaurane-3α,16β,17-triol Chemical Structure

ent-Kaurane-3α,16β,17-triol Chemical Structure

CAS No. : 130855-22-0

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ent-Kaurane-3α,16β,17-triol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1].

体外研究
(In Vitro)

ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) 抑制 HepG2 和 HCT116 细胞增殖，IC50 值分别为 45.5 和 29.84 µM[1]。
ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) 抑制 HCT116 细胞集落形成[1]。
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) 诱导人结肠癌细胞周期阻滞[1]。
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) 诱导人结肠癌细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ent-Kaurane-3α,16β,17-triol 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed inhibitory effects with IC50s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 48 h
Result: Significantly increased the cell population at the G0/G1 phase in a dosedependent manner.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 72 h
Result: Increased the percentage of both early and late apoptotic cells.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 30 μM
Incubation Time: 72 h
Result: Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2.
分子量

322.48

Formula

C20H34O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ent-Kaurane-3α,16β,17-triol 相关分类

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Keywords:

ent-Kaurane-3α,16β,17-triol130855-22-0ApoptosisHCT116PARPp27p53cyclin D1CDK2HepG2Inhibitorinhibitorinhibit

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