2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Immunology/Inflammation Apoptosis
  3. EGFR IFNAR Interleukin Related TNF Receptor Complement System Apoptosis
  4. Eps8 peptide 327

Eps8 peptide 327  (Synonyms: Eps8(327-335))

目录号: HY-P10994
产品使用指南 技术支持

Eps8 peptide 327 是一种源自 Eps8 蛋白的 HLA-A*2402 限制性肽抗原。Eps8 peptide 327 具有强效的抗肿瘤活性和显著细胞毒性。Eps8 peptide 327 可有效抑制癌细胞增殖，诱导细胞凋亡 (apoptosis)，并通过抑制下游信号 (如 IL-2, TNF-α 和 IFN-γ) 表达和Eps8/EGFR 相互作用来破坏 EGFR 信号通路。Eps8 peptide 327 显著抑制 HT-29 异种移植模型中的肿瘤生长。

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Eps8 peptide 327 Chemical Structure

Eps8 peptide 327 Chemical Structure

CAS No. : 1988684-26-9

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Eps8 peptide 327 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

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  • 参考文献

生物活性

Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from Eps8 protein. Eps8 peptide 327 has potent antitumor activity with significant cytotoxicity. Eps8 peptide 327 effectively inhibits cancer cells proliferation, induces apoptosis and disrupts EGFR signal pathway by inhibiting downstream signals (such as IL-2, TNF-α and IFN-γ) expression and the Eps8/EGFR interaction. Eps8 peptide 327 significantly inhibits tumor growth in HT-29 xenograft mcie models[1].

IC50 & Target[1]

IL-2

 

分子量

1176.34

Formula

C56H77N11O15S
CAS 号
Sequence

Glu-Phe-Leu-Asp-Cys-Phe-Gln-Lys-Phe
Sequence Shortening

EFLDCFQKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eps8 peptide 327 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eps8 peptide 3271988684-26-9Eps8(327-335)EGFRIFNARInterleukin RelatedTNF ReceptorComplement SystemApoptosisEpidermal growth factor receptorErbB-1HER1Interferon-α/β receptorInterferon-alpha/beta receptor ILTumor Necrosis Factor ReceptorTNFRHLA-A*2402Restricted peptide antigenEps8AntitumorA549 cellsColo320 cellsHepG2 cellsHT-29 cellsHT-29 xenograft mcie modelsInhibitorinhibitorinhibit

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