2. Apoptosis NF-κB Autophagy Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor PI3K/Akt/mTOR
  3. Apoptosis NF-κB Autophagy Reactive Oxygen Species (ROS) CDK PPAR FABP Akt mTOR
  4. Eriocalyxin B

Eriocalyxin B 是一种可以从中草药毛萼香茶菜中分离得到的二萜类化合物。Eriocalyxin B 具有抗癌、抗炎和抑制脂肪生成等多种活性。Eriocalyxin B 能够诱导肿瘤细胞凋亡 (apoptosis) 和自噬 (autophagy)。Eriocalyxin B 可用于癌症和自身免疫性疾病等的研究。

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Eriocalyxin B Chemical Structure

Eriocalyxin B Chemical Structure

CAS No. : 84745-95-9

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Eriocalyxin B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions[1][2][3][4][5].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.1 μM
Compound: 8
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 22624550]
HL-60 IC50
0.3 μM
Compound: 8
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 22624550]
MCF7 IC50
0.6 μM
Compound: 8
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 22624550]
SMMC-7721 IC50
0.8 μM
Compound: 8
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 22624550]
SW480 IC50
0.5 μM
Compound: 8
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 22624550]
体外研究
(In Vitro)

Eriocalyxin B (0-3.5 μM; 7 days) 在 3T3-L1 前脂肪细胞中抑制了脂肪生成 (IC50: 2.745 μM)，并抑制脂肪细胞分化关键调节因子 C/EBPα、C/EBPβ、PPARγ 和 FABP4 的表达[1]。
Eriocalyxin B (1.25-3.5 μM; 16-48 h) 可诱导分化的 3T3-L1 细胞在 G2/M 期停滞，并抑制细胞周期调节因子的表达水平[1]。
Eriocalyxin B (48 h) 对肿瘤细胞 A-549、MCF-7、SMMC-7721、SW-480 和 HL-60 等具有细胞毒性，IC50 在 0.3-3.1 μM之间[2]。
Eriocalyxin B (0.35-2.25 μM; 24-72 h) 可在 MCF-7 和 MDA-MB-231 中抑制细胞活力，增加细胞内 ROS 生成，并诱导细胞凋亡和自噬，机制涉及对 Akt/mTOR/p70S6K 信号通路的抑制[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eriocalyxin B 相关抗体:

Western Blot Analysis[1]

Cell Line: 3T3-L1 cells
Concentration: 1.25, 2.5, 3 and 3.5 μM
Incubation Time: 24 h
Result: Inhibited the levels of CDK1, CDK2, Cyclin A and Cyclin B1.
体内研究
(In Vivo)

Eriocalyxin B (10 mg/kg; 腹腔注射; 27 天) 在乳腺癌小鼠模型中具有抗肿瘤的活性[3]。
Eriocalyxin B (10 mg/kg; 腹腔注射; 18-28 天) 在实验性自身免疫性脑脊髓炎 (EAE) 小鼠模型中具有改善作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice aged 6-8 weeks old treated MDA-MB-231 cells[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); 27 days
Result: Led to a slower tumor growth rate and reduced final tumor weight.
Caused no significant change in body weight and liver enzyme levels in plasma (ALT, AST and LDH) after treatment.
Activated autophagy and apoptosis in vivo.
Animal Model: Female C57BL/6 mice aged 6-8 weeks old with EAE model[4]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); 11 days after or on the day of immunization for the treatment, continued until 28 days
Result: Led to amelioration of EAE, which correlated with reduced spinal cord inflammation and demyelination.
Abolished encephalitogenic T-cell responses to myelin oligodendrocyte glycoprotein in an adoptive transfer EAE model. The underlying mechanism of EriB-induced effects involved inhibition of T helper (Th) 1 and Th17 cell differentiation through Janus Kinase/Signal Transducer and Activator Of Transcription and Nuclear factor-κB signaling pathways as well as elevation of reactive oxygen species.
分子量

344.40

Formula

C20H24O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (58.07 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9036 mL 14.5180 mL 29.0360 mL
5 mM 0.5807 mL 2.9036 mL 5.8072 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.93%

COA (298 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Eriocalyxin B 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9036 mL 14.5180 mL 29.0360 mL 72.5900 mL
5 mM 0.5807 mL 2.9036 mL 5.8072 mL 14.5180 mL
10 mM 0.2904 mL 1.4518 mL 2.9036 mL 7.2590 mL
15 mM 0.1936 mL 0.9679 mL 1.9357 mL 4.8393 mL
20 mM 0.1452 mL 0.7259 mL 1.4518 mL 3.6295 mL
25 mM 0.1161 mL 0.5807 mL 1.1614 mL 2.9036 mL
30 mM 0.0968 mL 0.4839 mL 0.9679 mL 2.4197 mL
40 mM 0.0726 mL 0.3630 mL 0.7259 mL 1.8148 mL
50 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.4518 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eriocalyxin B84745-95-9ApoptosisNF-κBAutophagyReactive Oxygen Species (ROS)CDKPPARFABPAktmTORNuclear factor-κBNuclear factor-kappaBCyclin dependent kinasePeroxisome proliferator-activated receptorsFatty acid-binding proteinPKBProtein kinase BMammalian target of RapamycinEAE modelBreast cancer model 3T3-L1A-549MCF-7SMMC-7721SW-480HL-60MDA-MB-231Inhibitorinhibitorinhibit

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