1. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  2. Microtubule/Tubulin Apoptosis
  3. Estramustine phosphate sodium

Estramustine phosphate sodium  (Synonyms: 雌莫司汀磷酸钠)

目录号: HY-13627 纯度: 99.42%
COA 产品使用指南

Estramustine phosphate sodium,一种雌二醇类似物,是一种具有口服活性的抗微管化疗剂。Estramustine phosphate sodium 通过与微管相关蛋白 (MAP) 和/或微管蛋白结合而使微管解聚。Estramustine phosphate sodium 可干扰有丝分裂,引发细胞死亡,以及诱导细胞凋亡 (apoptosis),可用于前列腺癌等癌症相关的研究。

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Estramustine phosphate sodium Chemical Structure

Estramustine phosphate sodium Chemical Structure

CAS No. : 52205-73-9

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ¥447
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5 mg ¥360
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10 mg ¥600
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50 mg ¥990
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100 mg ¥1400
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500 mg   询价  

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Other Forms of Estramustine phosphate sodium:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].

体外研究
(In Vitro)

Estramustine phosphate sodium (1 µg/ mL, 48 h) suppresses PC3 cell growth[1].
Estramustine phosphate sodium (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31[1].
Estramustine phosphate sodium (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells[2].
Estramustine phosphate sodium (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC3 cells
Concentration: 1 µg/ mL
Incubation Time: 48 h
Result: Suppressed PC3 cell growth.

Immunofluorescence[2]

Cell Line: RAW 264.7 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Disrupted the interphase microtubules.

Cell Migration Assay [2]

Cell Line: 18 h of TGF-β treated RAW 264.7 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Inhibited TGF-β-Induced Cell Migration.
体内研究
(In Vivo)

Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors[3]
Dosage: 4 mg/kg, 12 mg/kg
Administration: Intraperitoneal injection; daily; for 2 weeks
Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
Animal Model: Human prostate cancer xenograft PAC120[3]
Dosage: 4 or 12 mg/kg, a daily dose for 2 weeks.
Administration: Intraperitoneal injection
Result: Inhibited PAC120 tumor growth 53% by day 35.
Clinical Trial
分子量

564.35

Formula

C23H30Cl2NNa2O6P

CAS 号
性状

固体

颜色

White to off-white

中文名称

雌莫司汀磷酸钠;雌莫司丁磷酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 62.5 mg/mL (110.75 mM; 超声助溶)

DMSO 中的溶解度 : 5 mg/mL (8.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7720 mL 8.8598 mL 17.7195 mL
5 mM 0.3544 mL 1.7720 mL 3.5439 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 65 mg/mL (115.18 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.42%

参考文献

Estramustine phosphate sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.7720 mL 8.8598 mL 17.7195 mL 44.2988 mL
5 mM 0.3544 mL 1.7720 mL 3.5439 mL 8.8598 mL
H2O 10 mM 0.1772 mL 0.8860 mL 1.7720 mL 4.4299 mL
15 mM 0.1181 mL 0.5907 mL 1.1813 mL 2.9533 mL
20 mM 0.0886 mL 0.4430 mL 0.8860 mL 2.2149 mL
25 mM 0.0709 mL 0.3544 mL 0.7088 mL 1.7720 mL
30 mM 0.0591 mL 0.2953 mL 0.5907 mL 1.4766 mL
40 mM 0.0443 mL 0.2215 mL 0.4430 mL 1.1075 mL
50 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8860 mL
60 mM 0.0295 mL 0.1477 mL 0.2953 mL 0.7383 mL
80 mM 0.0221 mL 0.1107 mL 0.2215 mL 0.5537 mL
100 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.4430 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Estramustine phosphate sodium
目录号:
HY-13627
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