2. Immunology/Inflammation
  3. CD19
  4. GBR-401

GBR-401 是一种人源化的抗 CD19 单克隆抗体，对 FcγRIIIa 具有高亲和力。GBR-401 对多种 B 细胞恶性肿瘤具有强大的体外和体内细胞毒性。GBR-401 通过抗体依赖性细胞毒性 (ADCC) 和直接杀伤作用诱导细胞死亡。GBR-401 在多种异种移植的重度联合免疫缺陷 (SCID) 小鼠模型中显示出强效的清除恶性 B 细胞能力，并延长小鼠存活时间。

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GBR-401 Chemical Structure

GBR-401 Chemical Structure

CAS No. : 1931954-95-8

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GBR-401 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GBR-401 is a humanized anti-CD19 monoclonal antibody with high affinity for FcγRIIIa. GBR-401 exerts a potent in vitro and in vivo cytotoxic activity against various B-cell malignancies. GBR-401 induces cell death by antibody dependent cellular cytotoxicity (ADCC) and direct killing effect. GBR-401 demonstrates potent activity of depleting malignant B cells and prolongs mice survival in multiple xenograft severe combined immunodeficiency (SCID) mice models[1].

IC50 & Target

CD19
体外研究
(In Vitro)

GBR-401 (0.00001-1 µg/ mL, 4-24 h) 对恶性 B 细胞、原发性 CLL 和淋巴瘤样本显示出明显优越的抗体依赖的细胞介导的细胞毒性 (ADCC) 活性[1]。

GBR-401 在 Raji、Ramos、SU-DHL-6、Namalwa、B-CLL 和 Lymphoma 细胞中抗体依赖性细胞毒性 (ADCC) 的 EC50 值分别为 1.2 ng/mL、0.9 ng/mL、0.8 ng/mL、2 ng/mL、1.6 ng/mL 和 15 ng/mL[1]。

GBR-401 (0.1-5000 ng/mL, 2 h) 可使 Mec-1、Raji 和 SU-DHL-6 细胞系中晚期凋亡/坏死死亡的细胞比例迅速增加[1]。

GBR-401 (1 μg/mL, 2 h) 在 Raji 细胞中通过诱导肌动蛋白重组，引发快速且强烈的同型聚集，从而诱导细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GBR-401 相关抗体:
体内研究
(In Vivo)

GBR-401 (0.005-10 mg/kg，腹腔注射，单剂量) 可引起人 PBMCs 异种移植小鼠模型中的 B 细胞耗竭[1]。

GBR-401 (2 mg/kg，腹腔注射，单剂量) 可显著减少人 CLL 细胞异种移植小鼠模型中的 B-CLL 细胞[1]。

GBR-401 (2 mg/kg，在第 3、7、10 天给药，共 3 次，) 可延长 Raji 细胞异种移植模型小鼠的中位生存时间并提高小鼠存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human PBMCs cells xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 0.005, 0.02, 0.1, 0.5, 2 and 10 mg/kg
Administration: Intraperitoneal injection
Result: Showed an EC50 value of 0.03 mg/kg and a maximum efficacy from 2 mg/kg with 84% reduction of the B cell population after 4 days.
Animal Model: Patient derived CLL and purified NK cells from healthy donors xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection
Result: Displayed a dramatic and significant reduction (92%) of B-CLL cells in the peritoneal cavity.
Animal Model: Raji cells xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 2 mg/kg
Administration: for 3 times at day 3, 7 and 9
Result: Significantly prolonged median survival time (51 days) and increased mice survival by 2.1 fold.
基因 ID

930  [NCBI]

Accession
靶点

CD19
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GBR-401 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GBR-4011931954-95-8GBR401GBR 401CD19B cell malignancies Anti-CD19 monoclonal antibodyADCCTherapeutic antibodyInhibitorinhibitorinhibit

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