1. Gene
  2. PRDX4 - peroxiredoxin 4 Gene

PRDX4 - peroxiredoxin 4 Gene

中文名称:过氧化物酶 4

种属: Homo sapiens

同用名: PRX-4; AOE372; AOE37-2; HEL-S-97n

基因 ID: 10549 | 基因类型: protein coding

关于 PRDX4

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,667,493-23,686,397 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 49.0), liver (RPKM 22.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种抗氧化酶,属于过氧化物酶家族。蛋白质定位于细胞质。过氧化物酶家族的过氧化物酶使用衍生自含硫醇供体分子的还原当量将过氧化氢和烷基氢过氧化物还原成水和醇。已发现这种蛋白质在转录因子 NF-kappaB 的激活中发挥调节作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is an antioxidant Enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

PRDX4 基因产物(1)

mRNA Protein Name
NM_006406.2 NP_006397.1 peroxiredoxin-4 precursor

PRDX4 蛋白结构

AhpC-TSA

AhpC-TSA: AhpC/TSA family (82 - 213)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (234 - 264)

  • 0
  • 100
  • 200
  • 271 a.a.
蛋白主名 其他名称

peroxiredoxin-4

antioxidant enzyme AOE372

重组 PRDX4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71232 PRDX4 Protein, Human (His) Q13162 (W38-N271) ≥95%

关联疾病

疾病名称 别名
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C

Filariasis

Disease Due To Superfamily Filarioidea

Bancroftian Filarial Fever

Mumu

Wanganga

Bancroftian Filariasis

Wuchereriosis

Brugiosis

Malayan Filariasis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PRDX4 VGNC VGNC:64347
Macaca mulatta PRDX4 VGNC VGNC:76272
Bos taurus PRDX4 VGNC VGNC:33302
Rattus norvegicus PRDX4 RGD RGD:620043
Canis familiaris PRDX4 VGNC VGNC:44952
Mus musculus PRDX4 MGD MGI:1859815
Others PRDX4 NCBI