1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR


iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品 (74):

Cat. No. Product Name Effect Purity
  • HY-15084
    (+)-MK 801 Maleate Antagonist 99.98%
    (+)-MK 801 Maleate 是一种有效的,选择性的,非竞争性的 nMDA 受体拮抗剂,Kd 值为 37.2 nM。
  • HY-17551
    NMDA Agonist >98.0%
    nMDA 是 nMDA receptor 的激动剂,能够模仿谷氨酸盐的活动。
  • HY-12882A
    Ifenprodil tartrate Antagonist 99.69%
    Ifenprodil tartrate 是 NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。
  • HY-12506
    Naspm Inhibitor
    Naspm(1-Naphthyl acetyl spermine)是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。
  • HY-106408
    Neu2000 Antagonist 99.09%
    Neu2000 是一种非竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。
  • HY-100714A
    D-AP5 Antagonist
    D-AP5 是一个 NMDA 受体拮抗剂。
  • HY-100785
    gamma-DGG Inhibitor >98.0%
    gamma-DGG 是一种竞争性的 AMPA 受体阻断剂。
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力, 能够抑制CYP2B6和YP2D6。
  • HY-15067
    DNQX Antagonist 98.46%
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor 98.49%
    Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂,对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。
  • HY-15084A
    (-)-MK 801 Maleate 99.70%
    (-)-MK 801马来酸盐是(_addition_)-MK-801的对映体,(_addition_)-MK-801是高效选择性NMDA受体拮抗剂。
  • HY-16312
    MDL-29951 Antagonist 98.50%
    MDL-29951 是一种新颖的 nMDA receptor 拮抗剂,能够抑制体内体外甘氨酸 ([3H]glycine) 的结合,Ki 值为 0.14 μM。
  • HY-17001
    Flupirtine Maleate Antagonist 99.97%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-12505
    CX546 Agonist 99.50%
  • HY-16728
    Rapastinel Modulator 99.49%
    Rapastinel (GLYX-13) 是一种N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂, 具有部分激动剂特性。
  • HY-16713A
    (S)-(-)-5-Fluorowillardiine hydrochloride Agonist 99.82%
  • HY-10935
    LY450108 Activator
  • HY-10934
    LY451395 Activator 99.47%