1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品 (68):

Cat. No. Product Name Effect Purity
  • HY-15084
    (+)-MK 801 Maleate Antagonist 99.94%
    (+)-MK 801 Maleate 是一种有效的,选择性的,非竞争性的 nMDA 受体拮抗剂,Kd 值为 37.2 nM。
  • HY-14745
    Perampanel Antagonist 99.82%
    Perampanel 是一种选择性的负变构 AMPA receptor 拮抗剂。Perampanel 抑制 AMPA 受体,IC50 为 0.23 µM,而不影响 NMDA 或红藻氨酸受体组分。
  • HY-12506
    Naspm Inhibitor
    Naspm(1-Naphthyl acetyl spermine)是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
  • HY-17551
    NMDA Agonist >98.0%
    nMDA 是 nMDA receptor 的激动剂,能够模仿谷氨酸盐的活动。
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 99.82%
    PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。
  • HY-B1333
    Dextromethorphan hydrobromide hydrate Antagonist 99.76%
    Dextromethorphan溴酸盐水合物是一种止咳药。
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力, 能够抑制CYP2B6和YP2D6。
  • HY-16312
    MDL-29951 Antagonist 98.50%
    MDL-29951 是一种新颖的 nMDA receptor 拮抗剂,能够抑制体内体外甘氨酸 ([3H]glycine) 的结合,Ki 值为 0.14 μM。
  • HY-12882A
    Ifenprodil tartrate Antagonist 99.69%
    Ifenprodil就是酸盐是NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX是一个AMPA受体的拮抗剂。
  • HY-16713A
    (S)-(-)-5-Fluorowillardiine hydrochloride Agonist
    (S)-(-)-5-Fluorowillardiine盐酸盐是AMPAR高效选择性激动剂。
  • HY-15084A
    (-)-MK 801 Maleate 99.70%
    (-)-MK 801马来酸盐是(_addition_)-MK-801的对映体,(_addition_)-MK-801是高效选择性NMDA受体拮抗剂。
  • HY-12505
    CX546 Agonist >98.0%
    CX546是AMPAR受体选择性激动剂。
  • HY-16728
    Rapastinel Modulator 99.49%
    Rapastinel (GLYX-13) 是一种N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂, 具有部分激动剂特性。
  • HY-17001
    Flupirtine Maleate Antagonist 99.93%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-10934
    LY451395 Activator 99.47%
    LY451395(Mibampator)是AMPA受体高选择性增强剂。
  • HY-10932
    Aniracetam Modulator 99.43%
    Aniracetam(Ro 13-5057)可调节AMPA受体和nAChR,具有神经保护和益智作用。
  • HY-17550
    Sunifiram Agonist 99.82%
    Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。
  • HY-12506A
    Naspm trihydrochloride Inhibitor >98.0%
    Naspm(1-Naphthyl acetyl spermine)trihydrochloride是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
  • HY-17456
    Noopept Agonist >98.0%
    Noopept (GVS-111)是可作为膳食补充剂的多肽。