1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品 (90):

Cat. No. Product Name Effect Purity
  • HY-15084
    (+)-MK 801 Maleate Antagonist 99.98%
    (+)-MK 801 Maleate 是一种有效,选择性,非竞争性的 NMDA 受体拮抗剂,Kd 值为 37.2 nM。
  • HY-15066
    CNQX Antagonist 98.05%
    CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。
  • HY-17551
    NMDA Agonist >98.0%
    nMDA 是 nMDA receptor 的激动剂,能够模仿谷氨酸盐的活动。
  • HY-12882A
    Ifenprodil tartrate Antagonist
    Ifenprodil tartrate 是 NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。
  • HY-12294A
    PEAQX tetrasodium hydrate Antagonist 98.22%
    PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。
  • HY-P1594A
    Dynorphin A (1-10) TFA Inhibitor
    Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽,与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流,IC50 为 42.0 μM。
  • HY-15068
    NBQX Antagonist 98.65%
    NBQX 是有效的 AMPAR 拮抗剂。IC50 值为 0.7 ± 0.1 μM。
  • HY-42068
    (-)-Aspartic acid Agonist
    (-)-Aspartic acid 是一种内源性 NMDA 受体激动剂。
  • HY-100714A
    D-AP5 Antagonist >98.0%
    D-AP5 是一个 NMDA 受体拮抗剂。
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力, 能够抑制CYP2B6和YP2D6。
  • HY-15067
    DNQX Antagonist 98.46%
    DNQX是一个AMPA受体的拮抗剂。
  • HY-13993A
    Ro 25-6981 Maleate Inhibitor 98.49%
    Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂,对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。
  • HY-15084A
    (-)-MK 801 Maleate 99.70%
    (-)-MK 801 Maleate 是 (+)-MK-801 的对映体,(+)-MK-801 是高效选择性,选择性的,非竞争性的 NMDA 受体拮抗剂。
  • HY-17001
    Flupirtine Maleate Antagonist 99.97%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-12506
    Naspm Inhibitor
    Naspm(1-Naphthyl acetyl spermine)是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
  • HY-10934
    Mibampator Activator 99.47%
    LY451395(Mibampator)是AMPA受体高选择性增强剂。
  • HY-15079
    Talampanel Antagonist 98.59%
    Talampanel是一种有效的选择性AMPA受体拮抗剂,是一个潜在的抗癫痫新药 (AED)。
  • HY-17555
    Meclofenoxate hydrochloride Activator
    Meclofenoxate盐酸盐是DMAE和pCPA合成的酯,有刺激记忆和提高认知的活性。
  • HY-12506A
    Naspm trihydrochloride Inhibitor >98.0%
    Naspm(1-Naphthyl acetyl spermine)trihydrochloride是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
  • HY-12505
    CX546 Agonist 99.50%
    CX546是AMPAR受体选择性激动剂。
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