MXD4 - MAX dimerization protein 4 Gene

中文名称：MAX 二聚化蛋白 4

种属: Homo sapiens

同用名: MAD4; MST149; MSTP149; bHLHc12

关于 MXD4

功能概要

该基因是 MAD 基因家族的成员。 MAD 基因编码基本的螺旋-环-螺旋-亮氨酸拉链蛋白，该蛋白与 MAX 蛋白异二聚化，形成转录抑制复合物。 MAD 蛋白与 MYC 竞争 MAX 结合，MYC 与 MAX 异二聚化形成转录激活复合物。对啮齿动物的研究表明，MAD 基因是肿瘤抑制基因，有助于调节分化组织中的细胞生长。[RefSeq 提供，2008 年 7 月]

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]