2. Gene
  3. HSPH1 - heat shock protein family H (Hsp110) member 1 Gene

HSPH1 - heat shock protein family H (Hsp110) member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 H (Hsp110) 成员 1

种属: Homo sapiens

同用名: HSP105; HSP105A; HSP105B; NY-CO-25

基因 ID: 10808 | 基因类型: protein coding

关于 HSPH1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:31,134,973-31,162,388 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues and 13 paralogues. Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues.

功能概要

该基因编码热休克蛋白 70 蛋白家族的成员。编码的蛋白质作为分子伴侣热休克同源 71 kDa 蛋白质 (Hsc70) 的核苷酸交换因子。此外，这种蛋白质作为抑制错误折叠蛋白质聚集的保持酶发挥着独特但相关的作用，包括囊性纤维化跨膜电导调节剂 (CFTR) 蛋白质。已在许多人类癌症中观察到这种蛋白质的表达升高。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

HSPH1 基因产物(12)

mRNA Protein Name
XM_017020364.3 XP_016875853.1 heat shock protein 105 kDa isoform X7
XM_017020363.3 XP_016875852.1 heat shock protein 105 kDa isoform X4
NM_001286503.2 NP_001273432.1 heat shock protein 105 kDa isoform 2
XM_011534888.3 XP_011533190.1 heat shock protein 105 kDa isoform X5
XM_011534887.4 XP_011533189.1 heat shock protein 105 kDa isoform X1
NM_001286505.1 NP_001273434.1 heat shock protein 105 kDa isoform 4
XM_005266236.3 XP_005266293.1 heat shock protein 105 kDa isoform X2
XM_047430058.1 XP_047286014.1 heat shock protein 105 kDa isoform X6
NM_006644.4 NP_006635.2 heat shock protein 105 kDa isoform 1
XM_017020362.3 XP_016875851.1 heat shock protein 105 kDa isoform X3
NM_001349704.2 NP_001336633.1 heat shock protein 105 kDa isoform 5
NM_001286504.1 NP_001273433.1 heat shock protein 105 kDa isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
24318877 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17024176 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9931472 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21231916 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23349634 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPH1 蛋白结构

HSP70

HSP70: Hsp70 protein (3 - 705)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
蛋白主名 其他名称

heat shock protein 105 kDa

antigen NY-CO-25

heat shock 105kDa/110kDa protein 1

HSPH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSPH1 Q92598 q96be0_human Homo sapiens Q96BE0
Lumier
25036637
种属间: 跨种属相互作用 种属内: 同种属相互作用

HSPH1 抗体

目录号 产品名 应用 反应物种
HY-P82868 Hsp110 Antibody (YA2613) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Craniotubular Dysplasia, Ikegawa Type

CTDI

Craniotubular Dysplasia Ikegawa Type

Doid:0112340
Photokeratitis
Craniodiaphyseal Dysplasia

Schaefer Stein Oshman Syndrome

CDD

Craniodiaphyseal Dysplasia, Dominant

Dominantly Inherited Craniodiaphyseal Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06450 HSPH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06451 Hsph1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06452 Hsph1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HSPH1 VGNC VGNC:106265
Felis catus HSPH1 VGNC VGNC:102230
Mus musculus HSPH1 MGD MGI:105053
Bos taurus HSPH1 VGNC VGNC:53817
Canis familiaris HSPH1 VGNC VGNC:59083
Rattus norvegicus HSPH1 RGD RGD:1311609
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