RIPK3 - receptor interacting serine/threonine kinase 3 Gene

中文名称：受体相互作用丝氨酸/苏氨酸激酶 3

种属: Homo sapiens

同用名: RIP3

基因 ID: 11035 | 基因类型: protein coding

关于 RIPK3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,336,025-24,339,991 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 245 orthologues and 23 paralogues. Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues.

功能概要

该基因的产物是丝氨酸/苏氨酸蛋白激酶受体相互作用蛋白 (RIP) 家族的成员，并且包含一个与其他 RIP 家族成员不同的 C 末端结构域。编码的蛋白质主要定位于细胞质，并且可以根据新的核定位和输出信号进行核质穿梭。它是肿瘤坏死因子 (TNF) 受体-I 信号复合物的组分，可诱导细胞凋亡并弱激活 NF-kappaB 转录因子。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from Other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce Apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

RIPK3 基因产物(1)

mRNA	Protein	Name
NM_006871.4	NP_006862.2	receptor-interacting serine/threonine-protein kinase 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	22817896	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19524512	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	22265413	GOA
enables protein kinase activity	IMP IMP: 通过突变表型推断	22817896	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	19524513	GOA
enables protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	22265414	GOA
enables protein-containing complex binding	IMP IMP: 通过突变表型推断	22265414	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of protein kinase activity	IMP IMP: 通过突变表型推断	22817896	GOA
involved in amyloid fibril formation	IMP IMP: 通过突变表型推断	22817896	GOA
involved in necroptotic process	IMP IMP: 通过突变表型推断	21737330	GOA
involved in necroptotic signaling pathway	IDA IDA: 通过直接分析推断	22265413	GOA
involved in necroptotic signaling pathway	IMP IMP: 通过突变表型推断	22265413	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	21931591	GOA
involved in positive regulation of necroptotic process	IDA IDA: 通过直接分析推断	22265414	GOA
involved in positive regulation of necroptotic process	IMP IMP: 通过突变表型推断	22817896	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	22265413	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	30271893	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	22817896	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RIPK3 蛋白结构

Pkinase

RHIM

0
100
200
300
400
518 a.a.

蛋白主名

其他名称

receptor-interacting serine/threonine-protein kinase 3

RIP-3	RIP-like protein kinase 3
receptor interacting protein 3

RIPK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265413
种属内	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Protein Kinase Assay	22265413
种属内	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265414
种属间	RIPK3	Q9Y572	ORF3a	Human SARS coronavirus	J9TC74	Confocal	30185776
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	19524512
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22265414
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Pull Down	22817896
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265414
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22817896
种属内	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265413
种属内	RIPK3	Q9Y572	ZBP1	Homo sapiens	Q9H171	Anti Tag CoIP	19590578

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RIPK3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71855	RIPK3 Protein, Human (P.pastoris, His)	Q9Y572-1 (M1-K518)	≥95%

RIPK3 抗体

目录号	产品名	应用	反应物种
HY-P86351	RIP3 Antibody (YA6043)	WB, ICC/IF, IP, ELISA	Mouse

关联疾病

疾病名称

别名

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b	Ceds
Alps2b	Caspase-8 Deficiency
Autoimmune Lymphoproliferative Syndrome, Type Iib	Alps With Recurrent Viral Infections
Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections	Caspase 8 Deficiency Syndrome
Autoimmune Lymphoproliferative Syndrome Type Iib	Caspase Eight Deficiency State
CASP8D

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Autoinflammation, Panniculitis, And Dermatosis Syndrome

Otulipenia	Otulin-Related Autoinflammatory Syndrome
AIPDS	Oras
Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome	Autoinflammation, Panniculitis And Dermatosis Syndrome
Otulin Deficiency

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101872	GSK-872	Inhibitor	99.91%	否
HY-101872A	GSK-872 hydrochloride	Inhibitor	99.21%	否
HY-104021	GSK840	Inhibitor	99.95%	否
HY-125402	GSK-843	Inhibitor	99.18%	否
HY-158312	UH15-38	Inhibitor	99.80%	否
HY-131064	RIPK3-IN-1	Inhibitor	99.30%	否
HY-N0546	Ligustroflavone	Inhibitor	99.90%	否
HY-148365	NecroIr1	Activator	98.02%	否
HY-N2909	Aurantiamide	Inhibitor	98.09%	否
HY-148366	NecroIr2	Activator	98.99%	否
HY-151873	SZM679	Inhibitor	99.59%	否
HY-173454	RIPK2/3-IN-2	Inhibitor	/	否
HY-171986	RIPK3-IN-6	Inhibitor	/	否
HY-149052	SZM-1209	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RIPK3	VGNC	VGNC:64642
Rattus norvegicus	RIPK3	RGD	RGD:628899
Mus musculus	RIPK3	MGD	MGI:2154952
Bos taurus	RIPK3	VGNC	VGNC:52818
Canis familiaris	RIPK3	VGNC	VGNC:110550
Others	RIPK3	NCBI

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