ATF6B - activating transcription factor 6 beta Gene

中文名称：激活转录因子 6 beta

种属: Homo sapiens

同用名: G13; CREBL1; CREB-RP

关于 ATF6B

功能概要

由该基因编码的蛋白质是内质网应激期间未折叠蛋白质反应 (UPR) 通路中的转录因子。作为同二聚体或与 ATF6-α 的异二聚体，编码的蛋白质与 ER 应激反应元件结合，与核转录因子 Y 相互作用以激活 UPR 靶基因。这种蛋白质通常存在于内质网膜中；然而，在 ER 应激下，N 末端胞质结构域从蛋白质的其余部分切割下来并转移到细胞核。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]