2. Gene
  3. Ripk2 - receptor (TNFRSF)-interacting serine-threonine kinase 2 Gene

Ripk2 - receptor (TNFRSF)-interacting serine-threonine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：受体 (TNFRSF) 相互作用的丝氨酸-苏氨酸激酶 2

种属: Mus musculus

同用名: CCK; RICK; RIP2; CARD3; CARDIAK; D4Bwg0615e; 2210420D18Rik

基因 ID: 192656 | 基因类型: protein coding

关于 Ripk2

Chromosome 4: 16,122,733-16,163,647 reverse strand.GRCm39:CM000997.3

This gene has 2 transcripts (splice variants), 207 orthologues, 23 paralogues and is associated with 9 phenotypes. Ubiquitous expression in ovary adult (RPKM 9.1), adrenal adult (RPKM 8.) and 28 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶受体相互作用蛋白家族的成员。编码的蛋白质包含一个 C 端半胱天冬酶激活和募集域，并且是先天性和适应性免疫途径中信号复合物的组成部分。它是核因子 kappa B 的有效激活剂和响应各种刺激的细胞凋亡诱导剂。交替剪接导致多个转录本变体。 [RefSeq 提供，2016 年 7 月]

This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal Caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of Apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Ripk2 基因产物(2)

mRNA Protein Name
NM_001329751.1 NP_001316680.1 receptor-interacting serine/threonine-protein kinase 2 isoform 2
NM_138952.4 NP_620402.1 receptor-interacting serine/threonine-protein kinase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
19473975 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of JNK cascade IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within T cell proliferation IMP
IMP: 通过突变表型推断
14638696 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
11894098 MGI
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
21469090 MGI
involved in adaptive immune response IMP
IMP: 通过突变表型推断
21469090 MGI
involved in canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21469090 MGI
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within cellular response to lipoteichoic acid IMP
IMP: 通过突变表型推断
11894098 MGI
involved in cellular response to muramyl dipeptide IDA
IDA: 通过直接分析推断
17947236 MGI
acts upstream of or within cellular response to peptidoglycan IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of chemokine production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
11894098 MGI
involved in innate immune response IMP
IMP: 通过突变表型推断
21469090 MGI
acts upstream of interleukin-2 production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of interleukin-6 production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
IMP: 通过突变表型推断
11894098 MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: 通过直接分析推断
17947236 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
14638696 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
21887730 MGI
acts upstream of or within positive regulation of T-helper 1 cell differentiation IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of T-helper 1 type immune response IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
14663141 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
17947236 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of chemokine production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
11894098 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
21887730 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
11894098 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
21887730 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within positive regulation of xenophagy IMP
IMP: 通过突变表型推断
22033934 MGI
NOT acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15190255 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within response to interleukin-1 IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of or within response to interleukin-12 IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within response to interleukin-18 IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of or within toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
11894098 MGI
acts upstream of type II interferon production IMP
IMP: 通过突变表型推断
11894097 MGI
acts upstream of xenophagy IMP
IMP: 通过突变表型推断
22033934 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ripk2 蛋白结构

STKc_RIP2

STKc_RIP2: cd14026 (19 - 302)

CARD_RIP2_CARD3

CARD_RIP2_CARD3: cd08786 (436 - 521)

  • 0
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  • 500
  • 539 a.a.
蛋白主名 其他名称

receptor-interacting serine/threonine-protein kinase 2

tyrosine-protein kinase RIPK2

Ripk2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ripk2 Q547H1 Rps27a Mus musculus P62991
Anti Tag CoIP
18079694
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-157442 GLPG3312 Inhibitor 98.57% Phase 1
HY-112038A GSK2983559 Inhibitor 98.82% Phase 1
HY-19764 GSK2983559 active metabolite Inhibitor 98.86% Phase 1
HY-112038 GSK2983559 free acid Inhibitor 99.90% Phase 1
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18937 WEHI-345 Inhibitor 99.31% 否
HY-111866 PROTAC RIPK degrader-2 Inhibitor 99.89% 否
HY-107978 RIPK-IN-4 Inhibitor 99.57% 否
HY-19628 OD36 Inhibitor 99.33% 否
HY-115630 cRIPGBM chloride 99.82% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-100112 WEHI-345 analog Inhibitor 98.41% 否
HY-136010 RIP2 Kinase Inhibitor 4 Inhibitor / 否
HY-171592 RIPK2-IN-7 Inhibitor / 否
HY-147235 RIPK2-IN-2 Inhibitor / 否
HY-159965 NOD1-RIPK2-IN-1 Inhibitor / 否
HY-173454 RIPK2/3-IN-2 Inhibitor / 否
HY-123924 CSLP37 Inhibitor / 否
HY-19628A OD36 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ripk2 NCBI NCBI:8767
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