Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

中文名称：含 Rho 相关卷曲螺旋蛋白激酶 1

种属: Mus musculus

同用名: Rock-I; 1110055K06Rik

关于 Rock1

功能概要

预测该基因编码的蛋白可启动 Rho 依赖性蛋白丝氨酸/苏氨酸激酶活性；天冬氨酸型内肽酶抑制剂活性；和小的 GTPase 结合活性。参与多个过程，包括肾小球内脏上皮细胞迁移；粘着斑装配的正调节；和对血管紧张素的反应。作用于多个过程的上游或内部，包括顶端收缩；气泡组装；和神经元凋亡过程的负调控。位于多种细胞成分中，包括细胞质应激颗粒；片状足；和荷叶边。以多种结构表达，包括中枢神经系统；泌尿生殖系统；直觉;心;和骨骼肌。与人 ROCK1 同源（Rho 相关的卷曲螺旋含有蛋白激酶 1）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including glomerular visceral epithelial cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]