ELF3 - E74 like ETS transcription factor 3 Gene

中文名称：E74 样 ETS 转录因子 3

种属: Homo sapiens

同用名: ERT; ESX; EPR-1; ESE-1

基因 ID: 1999 | 基因类型: protein coding

关于 ELF3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,010,587-202,017,183 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues, 28 paralogues and is associated with 62 phenotypes. Biased expression in colon (RPKM 88.6), stomach (RPKM 68.2) and 13 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和序列特异性双链 DNA 结合活性。参与炎症反应；转录的负调控，DNA 模板化；和 RNA 聚合酶 II 对转录的正调控。位于高尔基体；胞质溶胶；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in inflammatory response; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ELF3 基因产物(2)

mRNA	Protein	Name
NM_001114309.2	NP_001107781.1	ETS-related transcription factor Elf-3
NM_004433.5	NP_004424.3	ETS-related transcription factor Elf-3

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	9234700	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10391676	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in inflammatory response	IEP IEP: 通过表达模式推断	14715662	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10773884	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9234700	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELF3 蛋白结构

SAM_PNT

Ets

0
100
200
300
371 a.a.

蛋白主名

其他名称

ETS-related transcription factor Elf-3

E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)

ELF3 抗体

目录号	产品名	应用	反应物种
HY-P83039	ESE1 Antibody (YA2784)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Ampulla Of Vater Cancer

Ampulla Of Vater Carcinoma	Ampullary Carcinoma
Malignant Tumour Of Ampulla Of Vater	Carcinoma Of Ampulla Of Vater
Carcinoma Of The Ampulla Of Vater	Ampulloma

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Bladder
Transitional Cell Carcinoma Of The Bladder	Urinary Bladder Urothelial Carcinoma
Urothelial Bladder Carcinoma	Carcinoma Transitional Cell Bladder
Tcc - [Transitional Cell Carcinoma] Of Bladder

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Duodenum Cancer

Duodenal Cancer	Duodenal Neoplasms
Cancer Of Duodenum	Duodenal Neoplasm
Duodenal Carcinoma	Cancer, Duodenal
Malignant Neoplasm Of Duodenum

Ampulla Of Vater Adenocarcinoma

Adenocarcinoma Of Ampulla Of Vater

Ampullary Adenocarcinoma

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04300	ELF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-158005	Anticancer agent 195	Inducer	/	否
HY-RS17547	Efnb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18612	Elf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19817	Sptbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25098	Elf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ELF3	VGNC	VGNC:72207
Rattus norvegicus	ELF3	RGD	RGD:1310687
Bos taurus	ELF3	VGNC	VGNC:28428
Felis catus	ELF3	VGNC	VGNC:61807
Canis familiaris	ELF3	VGNC	VGNC:40300
Mus musculus	ELF3	MGD	MGI:1101781
Others	ELF3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ELF3 - E74 like ETS transcription factor 3 Gene

关于 ELF3

功能概要

ELF3 基因产物(2)

ELF3 蛋白结构

ELF3 抗体

关联疾病

直系同源

热门区域

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ELF3 - E74 like ETS transcription factor 3 Gene

关于 ELF3

功能概要

ELF3 基因产物(2)

ELF3 蛋白结构

ELF3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z