2. Gene
  3. Smarcb1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Gene

Smarcb1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ini1; Snf5; Baf47; SNF5/INI1

基因 ID: 20587 | 基因类型: protein coding

关于 Smarcb1

功能概要

Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching; cell differentiation; and negative regulation of cell population proliferation. Located in XY body and nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Used to study atypical teratoid rhabdoid tumor. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid Cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smarcb1 基因产物(2)

mRNA Protein Name
NM_001161853.1 NP_001155325.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform 2
NM_011418.2 NP_035548.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16287714 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blastocyst development IMP
IMP: 通过突变表型推断
11263494 MGI
acts upstream of or within blastocyst hatching IMP
IMP: 通过突变表型推断
11263494 MGI
acts upstream of or within hepatocyte differentiation IMP
IMP: 通过突变表型推断
16138077 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11095756 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF complex IDA
IDA: 通过直接分析推断
16287714 MGI
part of SWI/SNF superfamily-type complex IDA
IDA: 通过直接分析推断
12368262 MGI
located in XY body IDA
IDA: 通过直接分析推断
16787967 MGI
located in germ cell nucleus IDA
IDA: 通过直接分析推断
16787967 MGI
part of nBAF complex IDA
IDA: 通过直接分析推断
17640523 MGI
part of npBAF complex IDA
IDA: 通过直接分析推断
17640523 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16787967 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

BRG1-associated factor 47

SNF5 homolog

integrase interactor 1 protein

mSNF5

Smarcb1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Smarcb1 Q9Z0H3 Smarcc1 Mus musculus P97496
Anti Tag CoIP
17255092
种属内
Smarcb1 Q9Z0H3 Smarcc1 Mus musculus P97496
Confocal
17255092
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13803 Tazemetostat 99.93% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145925B CFT8634 Inhibitor 98.10% Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131246 DM-01 Inhibitor 98.03% 否
HY-RS13409 SMARCB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17520 Smarcb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23976 Smarcb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smarcb1 NCBI NCBI:6598
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