2. Gene
  3. Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Srebf1 - sterol regulatory element binding transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ADD1; SREBP1; bHLHd1

基因 ID: 20787 | 基因类型: protein coding

关于 Srebf1

功能概要

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]

Srebf1 基因产物(4)

mRNA Protein Name
NM_001313979.1 NP_001300908.1 sterol regulatory element-binding protein 1 isoform b
NM_001358314.1 NP_001345243.1 sterol regulatory element-binding protein 1 isoform c
NM_001358315.1 NP_001345244.1 sterol regulatory element-binding protein 1 isoform d
NM_011480.4 NP_035610.1 sterol regulatory element-binding protein 1 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11829742 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8833906 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
21531336 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16443825 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
15637161 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14654692 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19244231 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
14654692 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
16407292 MGI
acts upstream of cholesterol biosynthetic process IMP
IMP: 通过突变表型推断
9329978 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
19786558 MGI
acts upstream of or within fat cell differentiation IMP
IMP: 通过突变表型推断
22331133 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
17074803 MGI
acts upstream of insulin secretion IMP
IMP: 通过突变表型推断
16890542 MGI
involved in lipid biosynthetic process IDA
IDA: 通过直接分析推断
21459323 MGI
acts upstream of or within mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22331133 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
16890542 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17074803 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17636037 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11090130 MGI
involved in positive regulation of cholesterol biosynthetic process IDA
IDA: 通过直接分析推断
8833906 MGI
acts upstream of or within positive regulation of cholesterol biosynthetic process IMP
IMP: 通过突变表型推断
9329978 MGI
involved in positive regulation of innate immune response IMP
IMP: 通过突变表型推断
21531336 MGI
involved in positive regulation of lipid biosynthetic process IMP
IMP: 通过突变表型推断
21531336 MGI
involved in positive regulation of miRNA transcription IDA
IDA: 通过直接分析推断
23823476 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9329978 MGI
involved in positive regulation of triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
19244231 MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process IMP
IMP: 通过突变表型推断
16046411 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12242332 MGI
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21459323 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: 通过突变表型推断
19564420 MGI
acts upstream of or within regulation of heart rate by chemical signal IMP
IMP: 通过突变表型推断
18060044 MGI
acts upstream of or within regulation of insulin secretion IMP
IMP: 通过突变表型推断
18178930 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8833906 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21531336 MGI
acts upstream of or within response to glucose IMP
IMP: 通过突变表型推断
18178930 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16890542 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16100574 MGI
located in membrane IDA
IDA: 通过直接分析推断
11090130 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11090130 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sterol regulatory element-binding protein 1

adipocyte determination- and differentiation-dependent factor 1

Srebf1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Srebf1 Q9WTN3 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
20817729
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13757 SREBF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29460 SREBF1 Pig Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srebf1 NCBI NCBI:6720
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