2. Gene
  3. Srf - serum response factor Gene

Srf - serum response factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 20807 | 基因类型: protein coding

关于 Srf

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and nucleic acid binding activity. Involved in actin Cytoskeleton organization and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and generation of neurons. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including blastocyst; branchial arch; future forebrain; genitourinary system; and salivary gland. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Apr 2022]

Srf 基因产物(1)

mRNA Protein Name
NM_020493.2 NP_065239.1 serum response factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
21098124 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11439182 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
8900044 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21379568 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8900044 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: 通过遗传相互作用推断
11278942 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11439182 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
18458156 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
21379568 MGI
enables primary miRNA binding IDA
IDA: 通过直接分析推断
21303526 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11278942 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20534669 MGI
enables serum response element binding IDA
IDA: 通过直接分析推断
2062642 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
24732378 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
15837932 MGI
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
18804439 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
16600861 MGI
acts upstream of axon extension IMP
IMP: 通过突变表型推断
24623780 MGI
acts upstream of or within bicellular tight junction assembly IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
18804439 MGI
acts upstream of or within bronchus cartilage development IMP
IMP: 通过突变表型推断
24218621 MGI
involved in cardiac muscle cell myoblast differentiation IGI
IGI: 通过遗传相互作用推断
19783823 MGI
acts upstream of or within cardiac myofibril assembly IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within cardiac vascular smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
18804439 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: 通过突变表型推断
21401944 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: 通过突变表型推断
20525922 MGI
acts upstream of or within contractile actin filament bundle assembly IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within developmental growth IMP
IMP: 通过突变表型推断
9799237 MGI
acts upstream of or within dorsal aorta morphogenesis IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within epithelial cell-cell adhesion IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within epithelial structure maintenance IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within erythrocyte development IMP
IMP: 通过突变表型推断
20709909 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within eyelid development in camera-type eye IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within face development IMP
IMP: 通过突变表型推断
18952847 MGI
acts upstream of filopodium assembly IMP
IMP: 通过突变表型推断
18804439 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
20534669 MGI
acts upstream of or within gastrulation IMP
IMP: 通过突变表型推断
9799237 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15169892 MGI
acts upstream of or within heart looping IMP
IMP: 通过突变表型推断
15929941 MGI
acts upstream of or within heart trabecula formation IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
20709909 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
15837932 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9799237 MGI
acts upstream of or within leukocyte differentiation IMP
IMP: 通过突变表型推断
20709909 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: 通过突变表型推断
16600861 MGI
acts upstream of or within lung morphogenesis IMP
IMP: 通过突变表型推断
24218621 MGI
acts upstream of or within lung smooth muscle development IMP
IMP: 通过突变表型推断
24218621 MGI
acts upstream of or within megakaryocyte development IMP
IMP: 通过突变表型推断
20525922 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
9799237 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: 通过突变表型推断
15647354 MGI
involved in negative regulation of miRNA transcription IDA
IDA: 通过直接分析推断
21303526 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
15837932 MGI
acts upstream of or within neuron projection development IMP
IMP: 通过突变表型推断
19357276 MGI
acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
20525922 MGI
acts upstream of or within platelet formation IMP
IMP: 通过突变表型推断
20525922 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20534669 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19797053 MGI
acts upstream of or within positive regulation of axon extension IGI
IGI: 通过遗传相互作用推断
24623780 MGI
acts upstream of or within positive regulation of axon extension IMP
IMP: 通过突变表型推断
24623780 MGI
acts upstream of or within positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
18804439 MGI
involved in positive regulation of miRNA transcription IDA
IDA: 通过直接分析推断
19578358 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8900044 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12732141 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16510470 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15929941 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: 通过突变表型推断
21098124 MGI
acts upstream of or within primitive streak formation IMP
IMP: 通过突变表型推断
9799237 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12525493 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: 通过突变表型推断
18804439 MGI
acts upstream of or within sarcomere organization IMP
IMP: 通过突变表型推断
15569937 MGI
acts upstream of or within skin morphogenesis IMP
IMP: 通过突变表型推断
20047077 MGI
acts upstream of or within stress fiber assembly IMP
IMP: 通过突变表型推断
20525922 MGI
acts upstream of or within tangential migration from the subventricular zone to the olfactory bulb IMP
IMP: 通过突变表型推断
15837932 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
18952847 MGI
acts upstream of or within thyroid gland development IMP
IMP: 通过突变表型推断
18952847 MGI
acts upstream of or within trachea cartilage development IMP
IMP: 通过突变表型推断
24218621 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18511849 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15929941 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
16427017 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17576768 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15929941 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serum response factor

Srf 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Srf Q9JM73 Srebf2 Mus musculus Q3U1N2
Y2H
15102471
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P990068 Perenostobart 97.00% Phase 2
HY-P990024 Casdozokitug Inhibitor 96.49% Phase 2
HY-P99533 Urabrelimab Inhibitor 99.47% Phase 1
HY-P991061 CHS-114 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13991 CCG-1423 99.88% 否
HY-108361 CCG-203971 Inhibitor 99.89% 否
HY-120855 CCG-100602 Inhibitor 99.29% 否
HY-111432 CCG-232601 Inhibitor 99.00% 否
HY-153078 MRTF/SRF-IN-1 Inhibitor 99.68% 否
HY-118748 Suprafenacine Inhibitor ≥98.0% 否
HY-130011 CCG-232964 Inhibitor / 否
HY-162904 BPU17 / 否
HY-162968 MRTF-A-IN-1 Inhibitor / 否
HY-162969 MRTF-A-IN-2 Inhibitor / 否
HY-RS13760 SRF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17529 Srf Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23985 Srf Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srf NCBI NCBI:6722
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