1. Gene
  2. Xbp1 - X-box binding protein 1 Gene

Xbp1 - X-box binding protein 1 Gene

种属: Mus musculus

同用名: TREB5; XBP-1; TREB-5; D11Ertd39e

基因 ID: 22433 | 基因类型: protein coding

关于 Xbp1

功能概要

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; lipid homeostasis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; exocrine system development; and positive regulation of proteasomal protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Xbp1 基因产物(2)

mRNA Protein Name
NM_001271730.1 NP_001258659.1 X-box-binding protein 1 isoform XBP1(S)
NM_013842.3 NP_038870.2 X-box-binding protein 1 isoform XBP1(U)
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adipose tissue development IMP
IMP: 通过突变表型推断
23623498 MGI
involved in angiogenesis IMP
IMP: 通过突变表型推断
23529610 MGI
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
24753614 MGI
involved in cellular response to fructose stimulus IDA
IDA: 通过直接分析推断
18556558 MGI
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
17612490 MGI
involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
18556558 MGI
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
20348926 MGI
involved in cellular response to interleukin-4 IDA
IDA: 通过直接分析推断
12612580 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
12612580 MGI
involved in cellular response to nutrient IDA
IDA: 通过直接分析推断
20348926 MGI
involved in cellular response to peptide hormone stimulus IDA
IDA: 通过直接分析推断
23623498 MGI
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
18556558 MGI
involved in endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
16332684 MGI
involved in endoplasmic reticulum unfolded protein response IMP
IMP: 通过突变表型推断
14559994 MGI
involved in endothelial cell proliferation IMP
IMP: 通过突变表型推断
23529610 MGI
acts upstream of or within epithelial cell maturation involved in salivary gland development IMP
IMP: 通过突变表型推断
16362047 MGI
acts upstream of or within exocrine pancreas development IMP
IMP: 通过突变表型推断
16362047 MGI
involved in fatty acid homeostasis IMP
IMP: 通过突变表型推断
18556558 MGI
acts upstream of or within glandular epithelial cell maturation IMP
IMP: 通过突变表型推断
16362047 MGI
involved in intracellular triglyceride homeostasis IMP
IMP: 通过突变表型推断
18556558 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
19328063 MGI
involved in liver development IMP
IMP: 通过突变表型推断
10652269 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
10652269 MGI
involved in negative regulation of myotube differentiation IDA
IDA: 通过直接分析推断
17612490 MGI
involved in neuron development IDA
IDA: 通过直接分析推断
24753614 MGI
involved in positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
23623498 MGI
involved in positive regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
10652269 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: 通过直接分析推断
12612580 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
12612580 MGI
involved in positive regulation of lactation IMP
IMP: 通过突变表型推断
23623498 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23152784 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18556558 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
10652269 MGI
involved in protein destabilization IMP
IMP: 通过突变表型推断
24753614 MGI
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
24753614 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23623498 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
12612580 MGI
involved in response to insulin-like growth factor stimulus IDA
IDA: 通过直接分析推断
17612490 MGI
involved in sterol homeostasis IMP
IMP: 通过突变表型推断
18556558 MGI
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17612490 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
24753614 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16332684 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16332684 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

X-box-binding protein 1

tax-responsive element-binding protein 5 homolog

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xbp1 NCBI NCBI:7494