Xbp1 - X-box binding protein 1 Gene

种属: Mus musculus

同用名: TREB5; XBP-1; TREB-5; D11Ertd39e

基因 ID: 22433 | 基因类型: protein coding

关于 Xbp1

功能概要

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; lipid homeostasis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; exocrine system development; and positive regulation of proteasomal protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Xbp1 基因产物(2)

mRNA	Protein	Name
NM_001271730.1	NP_001258659.1	X-box-binding protein 1 isoform XBP1(S)
NM_013842.3	NP_038870.2	X-box-binding protein 1 isoform XBP1(U)

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	20408817	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	23152784	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17612490	MGI
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	20408817	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: 通过物理相互作用推断	20348926	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	8657566	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	18556558	MGI
enables ubiquitin-like protein ligase binding	IPI IPI: 通过物理相互作用推断	20408817	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adipose tissue development	IMP IMP: 通过突变表型推断	23623498	MGI
involved in angiogenesis	IMP IMP: 通过突变表型推断	23529610	MGI
involved in cellular response to amino acid stimulus	IDA IDA: 通过直接分析推断	24753614	MGI
involved in cellular response to fructose stimulus	IDA IDA: 通过直接分析推断	18556558	MGI
involved in cellular response to glucose starvation	IDA IDA: 通过直接分析推断	17612490	MGI
involved in cellular response to glucose stimulus	IDA IDA: 通过直接分析推断	18556558	MGI
involved in cellular response to insulin stimulus	IDA IDA: 通过直接分析推断	20348926	MGI
involved in cellular response to interleukin-4	IDA IDA: 通过直接分析推断	12612580	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: 通过表达模式推断	20439489	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	12612580	MGI
involved in cellular response to nutrient	IDA IDA: 通过直接分析推断	20348926	MGI
involved in cellular response to peptide hormone stimulus	IDA IDA: 通过直接分析推断	23623498	MGI
involved in cholesterol homeostasis	IMP IMP: 通过突变表型推断	18556558	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	16332684	MGI
involved in endoplasmic reticulum unfolded protein response	IMP IMP: 通过突变表型推断	14559994	MGI
involved in endothelial cell proliferation	IMP IMP: 通过突变表型推断	23529610	MGI
acts upstream of or within epithelial cell maturation involved in salivary gland development	IMP IMP: 通过突变表型推断	16362047	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: 通过突变表型推断	16362047	MGI
involved in fatty acid homeostasis	IMP IMP: 通过突变表型推断	18556558	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: 通过突变表型推断	16362047	MGI
involved in intracellular triglyceride homeostasis	IMP IMP: 通过突变表型推断	18556558	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	19328063	MGI
involved in liver development	IMP IMP: 通过突变表型推断	10652269	MGI
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	10652269	MGI
involved in negative regulation of myotube differentiation	IDA IDA: 通过直接分析推断	17612490	MGI
involved in neuron development	IDA IDA: 通过直接分析推断	24753614	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: 通过突变表型推断	23623498	MGI
involved in positive regulation of hepatocyte proliferation	IMP IMP: 通过突变表型推断	10652269	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: 通过直接分析推断	12612580	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: 通过直接分析推断	12612580	MGI
involved in positive regulation of lactation	IMP IMP: 通过突变表型推断	23623498	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23152784	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18556558	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10652269	MGI
involved in protein destabilization	IMP IMP: 通过突变表型推断	24753614	MGI
involved in regulation of autophagy	IMP IMP: 通过突变表型推断	24753614	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23623498	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	12612580	MGI
involved in response to insulin-like growth factor stimulus	IDA IDA: 通过直接分析推断	17612490	MGI
involved in sterol homeostasis	IMP IMP: 通过突变表型推断	18556558	MGI
involved in transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17612490	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	24753614	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16332684	MGI
located in nucleus	IDA IDA: 通过直接分析推断	16332684	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

X-box-binding protein 1

tax-responsive element-binding protein 5 homolog

目录号	产品名	作用方式	纯度	Phase
HY-104040	MKC8866	Inhibitor	99.95%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139214	IXA4	Inhibitor	98.83%	否
HY-103248	Toyocamycin		99.78%	否
HY-124293	AA147	Activator	99.81%	否
HY-100355	C18-Ceramide		99.95%	否
HY-139212	IXA6	Activator	99.29%	否
HY-124646	KIRA-7	Inhibitor	98.33%	否
HY-161672	G-5758	Inhibitor	98.91%	否
HY-U00460	3,6-DMAD hydrochloride	Inhibitor	99.50%	否
HY-176040	IXA62	Inhibitor	99.88%	否
HY-18509	IRE1α kinase-IN-2	Inhibitor	98.50%	否
HY-RS15865	XBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-145425	PAIR2	Antagonist	/	否
HY-158386	IRE1a-IN-1	Inhibitor	/	否
HY-158393	IRE1a-IN-2	Inhibitor	/	否
HY-168843	PSP205	Inducer	/	否
HY-169763	D-F07		/	否
HY-173497	IRE1-IN-2	Inhibitor	/	否
HY-U00460B	3,6-DMAD dihydrochloride	Inhibitor	/	否
HY-138844	3-AP-Me	Activator	/	否
HY-RS16677	Xbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23112	Xbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Xbp1	NCBI	NCBI:7494

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Xbp1 - X-box binding protein 1 Gene

关于 Xbp1

功能概要

Xbp1 基因产物(2)

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Xbp1 - X-box binding protein 1 Gene

关于 Xbp1

功能概要

Xbp1 基因产物(2)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z