2. Gene
  3. VASH1 - vasohibin 1 Gene

VASH1 - vasohibin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管抑制素 1

种属: Homo sapiens

同用名: TTCP 1; KIAA1036

基因 ID: 22846 | 基因类型: protein coding

关于 VASH1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:76,761,468-76,783,015 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 12.0), placenta (RPKM 11.8) and 25 other tissues.

功能概要

启用肌动蛋白结合活性和金属羧肽酶活性。参与血管生成的负调节；血管内皮细胞迁移的负调控；和蛋白水解。作用于几个过程的上游或内部，包括内皮细胞迁移的负调节；内皮细胞增殖的负调节；和淋巴管生成的负调节。位于细胞顶端；内质网；和细胞外空间。与肝硬化和门静脉高压有关。肝硬化的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Apr 2022]

VASH1 基因产物(1)

mRNA Protein Name
NM_014909.5 NP_055724.1 tubulinyl-Tyr carboxypeptidase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
29146869 GOA
enables metallocarboxypeptidase activity IDA
IDA: 通过直接分析推断
29146869 GOA
enables metallocarboxypeptidase activity IMP
IMP: 通过突变表型推断
31171830 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IDA
IDA: 通过直接分析推断
15467828 GOA
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
15467828 GOA
acts upstream of or within negative regulation of angiogenesis IGI
IGI: 通过遗传相互作用推断
20133819 GOA
involved in negative regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
15467828 GOA
acts upstream of or within negative regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
19204325 GOA
involved in negative regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
15467828 GOA
acts upstream of or within negative regulation of lymphangiogenesis IGI
IGI: 通过遗传相互作用推断
20133819 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
29146869 GOA
acts upstream of or within regulation of cellular senescence IMP
IMP: 通过突变表型推断
23056314 GOA
acts upstream of or within response to wounding IDA
IDA: 通过直接分析推断
23056314 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
20736312 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15467828 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15467828 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
15467828 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VASH1 蛋白结构

Vasohibin

Vasohibin: Vasohibin (57 - 302)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
蛋白主名 其他名称

tubulinyl-Tyr carboxypeptidase 1

tubulin carboxypeptidase 1

VASH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VASH1 Q7L8A9 DHPS Homo sapiens P49366
Validated Y2H
25416956
种属内
VASH1 Q7L8A9 DHPS Homo sapiens P49366
Y2H Prey Pooling
25416956
种属内
VASH1 Q7L8A9 DHPS Homo sapiens P49366
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Portal Hypertension

Hypertension, Portal

Hypertension Portal

Pht - [Portal Hypertension]

Portal Htn
Myasthenic Syndrome, Congenital, 14

Congenital Myasthenic Syndrome 14

CMS14

Cmsta3

Myasthenic Syndrome, Congenital, With Tubular Aggregates 3

Myasthenic Syndrome, Congenital, 14, With Tubular Aggregates

Congenital Myasthenic Syndrome 14, With Tubular Aggregates

Congenital Myasthenic Syndrome With Tubular Aggregates 3

Myasthenic Syndrome, Congenital, With Tubular Aggregates, 3

Myasthenic Syndrome, Congenital, Type 14, With Tubular Aggregates
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148542 EpoY 98.8% 否
HY-RS15606 VASH1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris VASH1 VGNC VGNC:48233
Mus musculus VASH1 MGD MGI:2442543
Macaca mulatta VASH1 VGNC VGNC:79213
Felis catus VASH1 VGNC VGNC:80810
Rattus norvegicus VASH1 RGD RGD:1564082
Bos taurus VASH1 VGNC VGNC:36767
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