2. Gene
  3. LIMCH1 - LIM and calponin homology domains 1 Gene

LIMCH1 - LIM and calponin homology domains 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：LIM 和 calponin 同源域 1

种属: Homo sapiens

同用名: LMO7B; LIMCH1A

基因 ID: 22998 | 基因类型: protein coding

关于 LIMCH1

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,359,607-41,700,044 (from NCBI)

This gene has 22 transcripts (splice variants), 243 orthologues and 1 paralogue. Broad expression in lung (RPKM 19.3), spleen (RPKM 14.7) and 20 other tissues.

功能概要

启用肌球蛋白 II 头/颈结合活动。参与多个过程，包括参与细胞运动的基于细胞质肌动蛋白的收缩；应力纤维组装的正向调控；粘着斑组装的调节。位于应力纤维中。与肌球蛋白 II 复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables Myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with Myosin II complex. [provided by Alliance of Genome Resources, Apr 2022]

LIMCH1 基因产物(20)

mRNA Protein Name
NM_001112717.4 NP_001106188.1 LIM and calponin homology domains-containing protein 1 isoform b
NM_001112718.4 NP_001106189.1 LIM and calponin homology domains-containing protein 1 isoform c
NM_001112719.4 NP_001106190.1 LIM and calponin homology domains-containing protein 1 isoform d
NM_001112720.4 NP_001106191.1 LIM and calponin homology domains-containing protein 1 isoform e
NM_001289122.3 NP_001276051.1 LIM and calponin homology domains-containing protein 1 isoform f
NM_001289124.2 NP_001276053.1 LIM and calponin homology domains-containing protein 1 isoform g
NM_001330672.2 NP_001317601.1 LIM and calponin homology domains-containing protein 1 isoform h
NM_001330674.2 NP_001317603.1 LIM and calponin homology domains-containing protein 1 isoform i
NM_001330784.2 NP_001317713.1 LIM and calponin homology domains-containing protein 1 isoform j
NM_001330786.2 NP_001317715.1 LIM and calponin homology domains-containing protein 1 isoform k
NM_001330787.2 NP_001317716.1 LIM and calponin homology domains-containing protein 1 isoform l
NM_001330788.2 NP_001317717.1 LIM and calponin homology domains-containing protein 1 isoform m
NM_001330789.2 NP_001317718.1 LIM and calponin homology domains-containing protein 1 isoform n
NM_001330790.2 NP_001317719.1 LIM and calponin homology domains-containing protein 1 isoform o
NM_001330791.2 NP_001317720.1 LIM and calponin homology domains-containing protein 1 isoform p
NM_001330792.2 NP_001317721.1 LIM and calponin homology domains-containing protein 1 isoform q
NM_001330793.2 NP_001317722.1 LIM and calponin homology domains-containing protein 1 isoform r
NM_001330982.2 NP_001317911.1 LIM and calponin homology domains-containing protein 1 isoform s
NM_001330983.1 NP_001317912.1 LIM and calponin homology domains-containing protein 1 isoform t
NM_014988.5 NP_055803.2 LIM and calponin homology domains-containing protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables myosin II head/neck binding IDA
IDA: 通过直接分析推断
28228547 GOA
enables myosin II head/neck binding IPI
IPI: 通过物理相互作用推断
28228547 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30429017 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic actin-based contraction involved in cell motility IMP
IMP: 通过突变表型推断
28228547 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
28228547 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
28228547 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
28228547 GOA
involved in regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
28228547 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of myosin II complex IDA
IDA: 通过直接分析推断
28228547 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
28228547 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIMCH1 蛋白结构

CH

CH: Calponin homology (CH) domain (28 - 133)

LIM

LIM: LIM domain (1013 - 1074)

  • 0
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  • 400
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  • 800
  • 1000
  • 1083 a.a.
蛋白主名 其他名称

LIM and calponin homology domains-containing protein 1

LIMCH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIMCH1 Q9UPQ0 KLHL15 Homo sapiens Q96M94
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07658 LIMCH1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LIMCH1 VGNC VGNC:42678
Mus musculus LIMCH1 MGD MGI:1924819
Felis catus LIMCH1 VGNC VGNC:63229
Bos taurus LIMCH1 VGNC VGNC:30887
Macaca mulatta LIMCH1 VGNC VGNC:74155
Rattus norvegicus LIMCH1 RGD RGD:1305269
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