2. Gene
  3. Numb - NUMB, endocytic adaptor protein Gene

Numb - NUMB, endocytic adaptor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29419 | 基因类型: protein coding

关于 Numb

功能概要

Predicted to enable alpha-catenin binding activity; beta-catenin binding activity; and Cadherin binding activity. Involved in positive regulation of dendrite morphogenesis; regulation of neuron differentiation; and regulation of postsynaptic specialization assembly. Located in apical part of cell and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Numb 基因产物(5)

mRNA Protein Name
NM_001411953.1 NP_001398882.1 protein numb homolog isoform 2
NM_001411954.1 NP_001398883.1 protein numb homolog isoform 1
NM_001411955.1 NP_001398884.1 protein numb homolog isoform 3
NM_001411956.1 NP_001398885.1 protein numb homolog isoform 4
NM_133287.2 NP_579821.2 protein numb homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16394100 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
16394100 RGD
involved in regulation of neuron differentiation IMP
IMP: 通过突变表型推断
8805372 RGD
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
16394100 RGD
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
16394100 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
12702648 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16394100 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16394100 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
16394100 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
16394100 RGD
is active in postsynaptic density IMP
IMP: 通过突变表型推断
16394100 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein numb homolog

numb gene homolog

numb homolog

Numb 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Numb Q3MUI1 Ap2a2 Rattus norvegicus Q66HM2
Pull Down
17022975
种属内
Numb Q3MUI1 Ywhah Rattus norvegicus P68511
Pull Down
17022975
种属内
Numb Q3MUI1 Ap2b1 Rattus norvegicus P62944-2
Pull Down
17022975
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119734 Gossypolone 96.63% 否
HY-N7013 Hydroxy-Epsilon-Sanshool / 否
HY-N7014 Hydroxyl-​γ-​isosanshool / 否
HY-RS09681 NUMB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19926 Numb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26428 Numb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Numb NCBI NCBI:8650
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