2. Gene
  3. Hes1 - hes family bHLH transcription factor 1 Gene

Hes1 - hes family bHLH transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29577 | 基因类型: protein coding

关于 Hes1

功能概要

Enables several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; generation of neurons; and regulation of gene expression. Located in chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hes1 基因产物(1)

mRNA Protein Name
NM_024360.4 NP_077336.3 transcription factor HES-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9389649 RGD
enables E-box binding IDA
IDA: 通过直接分析推断
19670267 RGD
enables JUN kinase binding IPI
IPI: 通过物理相互作用推断
22302822 RGD
enables N-box binding IDA
IDA: 通过直接分析推断
22302822 RGD
enables chromatin binding IDA
IDA: 通过直接分析推断
15607978 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9389649 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8687460 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
11238932 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11486045 RGD
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
8687460 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
19272428 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
23589286 RGD
involved in cellular response to nerve growth factor stimulus IMP
IMP: 通过突变表型推断
9389649 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
23589286 RGD
involved in forebrain radial glial cell differentiation IDA
IDA: 通过直接分析推断
11399758 RGD
involved in hair cell differentiation IMP
IMP: 通过突变表型推断
11023859 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8649374 RGD
involved in negative regulation of calcium ion import IMP
IMP: 通过突变表型推断
22302822 RGD
involved in negative regulation of forebrain neuron differentiation IDA
IDA: 通过直接分析推断
11399758 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
19670267 RGD
involved in negative regulation of neurogenesis IMP
IMP: 通过突变表型推断
11399758 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
9389649 RGD
involved in negative regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
12666205 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8649374 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11486045 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
9634594 RGD
involved in neuronal stem cell population maintenance IDA
IDA: 通过直接分析推断
11399758 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
15607978 RGD
involved in positive regulation of glial cell differentiation IMP
IMP: 通过突变表型推断
10839357 RGD
involved in regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
22302822 RGD
involved in response to alkaloid IEP
IEP: 通过表达模式推断
23545940 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
15862623 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
15862623 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
15607978 RGD
located in nuclear matrix IDA
IDA: 通过直接分析推断
11035023 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor HES-1

RHL

hairy and enhancer of split 1

hairy-like protein

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19369 L-685458 99.48% 否
HY-117113 JI051 Inhibitor ≥98.0% 否
HY-107245 Segetalin B 99.51% 否
HY-164410 MO-I-1100 Inhibitor 99.76% 否
HY-124484 JI130 Inhibitor 99.01% 否
HY-RS06134 HES1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-N3393 Lethedioside A / 否
HY-RS17070 Hes1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23514 Hes1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hes1 NCBI NCBI:3280
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