PADI1 - peptidyl arginine deiminase 1 Gene

中文名称：肽基精氨酸脱亚胺酶 1

种属: Homo sapiens

同用名: PDI; PAD1; PDI1; HPAD10

关于 PADI1

功能概要

该基因编码肽基精氨酸脱亚胺酶家族的成员，该酶通过在钙离子存在下将精氨酸残基转化为瓜氨酸来催化蛋白质的翻译后脱亚胺。该家族成员具有不同的底物特异性和组织特异性表达模式。 I 型酶参与表皮分化的后期阶段，在那里它去除聚丝蛋白和角蛋白 K1，从而维持角质层的水合作用，从而维持皮肤屏障功能。这种酶也可能在毛囊形成中发挥作用。该基因与其他四个旁系同源基因存在于一个簇中。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four Other paralogous genes. [provided by RefSeq, Jul 2008]