2. Gene
  3. Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 306782 | 基因类型: protein coding

关于 Ror2

功能概要

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and positive regulation of protein serine/threonine kinase activity. Located in several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like Orphan Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ror2 基因产物(1)

mRNA Protein Name
NM_001107339.1 NP_001100809.1 tyrosine-protein kinase transmembrane receptor ROR2 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte development IDA
IDA: 通过直接分析推断
15095375 RGD
involved in bone mineralization IEP
IEP: 通过表达模式推断
23337931 RGD
involved in macrophage migration IMP
IMP: 通过突变表型推断
25749876 RGD
involved in male genitalia development IEP
IEP: 通过表达模式推断
23895974 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26311509 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26311509 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
25825749 RGD
involved in positive regulation of macrophage differentiation IMP
IMP: 通过突变表型推断
25749876 RGD
involved in positive regulation of protein kinase C activity IMP
IMP: 通过突变表型推断
25825749 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
25825749 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
26003414 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
26003414 RGD
involved in regulation of synaptic signaling by nitric oxide IDA
IDA: 通过直接分析推断
26311509 RGD
involved in regulation of synaptic signaling by nitric oxide IMP
IMP: 通过突变表型推断
26311509 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15095375 RGD
located in dendrite IDA
IDA: 通过直接分析推断
25825749 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26003414 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26003414 RGD
located in microtubule IDA
IDA: 通过直接分析推断
15095375 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
25825749 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
26003414 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase transmembrane receptor ROR2

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145626 Ozuriftamab 99.73% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12125 ROR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12126 RORA Human Pre-designed siRNA Set A / 否
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / 否
HY-RS17495 Ror2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23952 Ror2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145627 Ozuriftamab vedotin Inhibitor 99.65% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ror2 NCBI NCBI:4920
Macaca fascicularis Ror2 NCBI NCBI:102118636
Mus musculus Ror2 NCBI NCBI:26564
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