1. Gene
  2. Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

种属: Mus musculus

同用名: Ntrkr2

基因 ID: 26564 | 基因类型: protein coding

关于 Ror2

功能概要

Enables Wnt-protein binding activity; Frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and embryonic morphogenesis. Predicted to be located in several cellular components, including dendrite; microtubule; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like Orphan Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ror2 基因产物(1)

mRNA Protein Name
NM_013846.4 NP_038874.3 tyrosine-protein kinase transmembrane receptor ROR2 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
18606138 MGI
enables frizzled binding IPI
IPI: 通过物理相互作用推断
12839624 MGI
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: 通过物理相互作用推断
18762249 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12839624 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within JNK cascade IDA
IDA: 通过直接分析推断
12839624 MGI
acts upstream of or within SMAD protein signal transduction IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within Wnt signaling pathway, calcium modulating pathway IPI
IPI: 通过物理相互作用推断
12839624 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
18606138 MGI
acts upstream of or within cartilage condensation IMP
IMP: 通过突变表型推断
14745966 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: 通过突变表型推断
14745966 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
20660756 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within embryonic genitalia morphogenesis IMP
IMP: 通过突变表型推断
14745966 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: 通过突变表型推断
18606138 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
16602827 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18215320 MGI
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18215320 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
10700181 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within somitogenesis IMP
IMP: 通过突变表型推断
14745966 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase transmembrane receptor ROR2

neurotrophic tyrosine kinase, receptor-related 2

重组 Ror2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78687 ROR2 Protein, Mouse (HEK293, Fc) Q9Z138 (E34-G403) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ror2 NCBI NCBI:4920
Macaca fascicularis Ror2 NCBI NCBI:102118636