1. Gene
  2. DUOX2 - dual oxidase 2 Gene

DUOX2 - dual oxidase 2 Gene

中文名称:双氧化酶 2

种属: Homo sapiens

同用名: TDH6; LNOX2; THOX2; NOXEF2; P138-TOX

基因 ID: 50506 | 基因类型: protein coding

关于 DUOX2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,092,650-45,114,172 (from NCBI)

This gene has 5 transcripts (splice variants), 129 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 216.4), thyroid (RPKM 55.7) and 3 other tissues.

功能概要

该基因编码的蛋白质是一种糖蛋白,是 NADPH 氧化酶家族的成员。甲状腺激素的合成由位于甲状腺滤泡细胞顶膜的蛋白质复合物催化。该复合物包含碘化物转运蛋白、甲状腺过氧化物酶和包含该编码蛋白和 DUOX1 的过氧化物生成系统。这种蛋白质被称为双氧化酶,因为它同时具有过氧化物酶同源结构域和 gp91phox 结构域。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a glycoprotein and a member of the NADPH Oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]

DUOX2 基因产物(2)

mRNA Protein Name
NM_001363711.2 NP_001350640.1 dual oxidase 2 isoform 2 precursor
NM_014080.5 NP_054799.4 dual oxidase 2 isoform 1 precursor

DUOX2 蛋白结构

An_peroxidase

An_peroxidase: Animal haem peroxidase (36 - 560)

EF-hand_7

EF-hand_7: EF-hand domain pair (826 - 884)

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (1085 - 1233)

FAD_binding_8

FAD_binding_8: FAD-binding domain (1271 - 1369)

NAD_binding_6

NAD_binding_6: Ferric reductase NAD binding domain (1377 - 1531)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1548 a.a.
蛋白主名 其他名称

dual oxidase 2

NADH/NADPH thyroid oxidase p138-tox

DUOX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DUOX2 Q9NRD8 DUOXA2 Homo sapiens Q1HG44 25761904
种属内
DUOX2 Q9NRD8 DUOXA2 Homo sapiens Q1HG44 25761904
种属内
DUOX2 Q9NRD8 DUOXA2 Homo sapiens Q1HG44 25761904
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Thyroid Dyshormonogenesis 6

TDH6

Genetic Defect In Thyroid Hormonogenesis 6

Thyroid Hormonogenesis, Genetic Defect In, 6

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6

Chdh6

Congenital Hypothyroidism Due To Dyshormonogenesis Type 6

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Genetic Transient Congenital Hypothyroidism
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos

Hypothyroidism

Thyroid Diseases

Thyroid Disease

Thyroid Deficiency

Thyroid Insufficiency

Dysfunction Thyroid

Thyroid Dysfunction

Pendred Syndrome

Goiter-Deafness Syndrome

Deafness With Goiter

PDS

Thyroid Dyshormonogenesis 2b

Tdh2b

Autosomal Recessive Sensorineural Hearing Impairment And Goiter

Pendred'S Syndrome

Thyroid Hormonogenesis, Genetic Defect In, 2b

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b

Congenital Hypothyroidism Due To Dyshormonogenesis 2b

Genetic Defect In Thyroid Hormonogenesis 2b

Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter

Goiter-Hearing Loss Syndrome

Goitre-Deafness Syndrome

Goitre Deafness

Goiter

Goitre

Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis

Colitis
Granulomatous Disease, Chronic, Autosomal Recessive, 4

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative

Cyba Deficiency

CGD4

Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative

Cgd, Autosomal Recessive Cytochrome B-Negative

Chronic Granulomatous Disease 4, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 4

Autosomal Recessive Cytochrome B-Negative Cgd

Chronic Granulomatous Disease Due To Deficiency Of Cyba

Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative

Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Dyshormonogenic Goiter

Dyshormonogenic Goitre

Ileocolitis

Iieocolitis

Constipation
Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Granulomatous Disease, Chronic, X-Linked

CGDX

Chronic Granulomatous Disease, X-Linked

X-Linked Chronic Granulomatous Disease

Cgd

Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

Cdgx

X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

Granulomatous Disease, Chronic, X-Linked, Variant

Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate

Bamforth-Lazarus Syndrome

Bamforth Syndrome

Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome

Hypothyroidism-Cleft Palate Syndrome

BLS

Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DUOX2 MGD MGI:3036280
Rattus norvegicus DUOX2 RGD RGD:628761
Felis catus DUOX2 VGNC VGNC:61654
Bos taurus DUOX2 VGNC VGNC:28242
Canis familiaris DUOX2 VGNC VGNC:40121
Macaca mulatta DUOX2 VGNC VGNC:71833