MESP1 - mesoderm posterior bHLH transcription factor 1 Gene

中文名称：中胚层后部 bHLH 转录因子 1

种属: Homo sapiens

同用名: bHLHc5

基因 ID: 55897 | 基因类型: protein coding

关于 MESP1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,732,446-89,751,249 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 2 paralogues. Biased expression in fat (RPKM 4.6), prostate (RPKM 4.1) and 4 other tissues.

功能概要

启用 DNA 结合转录因子活性和转录顺式调节区结合活性。参与多个过程，包括内皮细胞分化；心脏发育；和 RNA 聚合酶 II 对转录的正调控。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including endothelial cell differentiation; heart development; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MESP1 基因产物(1)

mRNA	Protein	Name
NM_018670.4	NP_061140.1	mesoderm posterior protein 1

MESP1 蛋白结构

HLH

0
100
200
268 a.a.

蛋白主名

其他名称

mesoderm posterior protein 1

class C basic helix-loop-helix protein 5

MESP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

MESP1 抗体

目录号	产品名	应用	反应物种
HY-P85278	MESP1 Antibody (YA4970)	WB, ELISA	Human

关联疾病

疾病名称

别名

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Cardiomyopathy, Dilated, 1x

Dilated Cardiomyopathy 1x	CMD1X
Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness	Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness
Cardiomyopathy, Dilated 1x	Cardiomyopathy, Dilated, Type 1x

Mongolian Spot

Mongolian Macula

Dysostosis

Dysostoses

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08342	MESP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20447	Mesp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26956	Mesp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MESP1	VGNC	VGNC:63453
Macaca mulatta	MESP1	VGNC	VGNC:74618
Canis familiaris	MESP1	VGNC	VGNC:43163
Mus musculus	MESP1	MGD	MGI:107785
Rattus norvegicus	MESP1	RGD	RGD:1311751
Bos taurus	MESP1	VGNC	VGNC:106820

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