2. Gene
  3. Diaph3 - diaphanous related formin 3 Gene

Diaph3 - diaphanous related formin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dia2; Drf3; Diap3; p134MDia2; 4930417P13Rik

基因 ID: 56419 | 基因类型: protein coding

关于 Diaph3

功能概要

Predicted to enable actin binding activity and small GTPase binding activity. Involved in actin filament polymerization. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; gonad; spleen; and vibrissa. Used to study autosomal dominant auditory neuropathy 1 and congenital dyserythropoietic anemia. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3). [provided by Alliance of Genome Resources, Apr 2022]

Diaph3 基因产物(1)

mRNA Protein Name
NM_019670.2 NP_062644.1 protein diaphanous homolog 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
16556604 MGI
enables cytoskeletal protein binding IDA
IDA: 通过直接分析推断
16556604 MGI
enables microtubule binding IDA
IDA: 通过直接分析推断
18458159 MGI
enables microtubule binding IMP
IMP: 通过突变表型推断
18458159 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15976449 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16556604 MGI
enables protein homodimerization activity IMP
IMP: 通过突变表型推断
18458159 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin crosslink formation IDA
IDA: 通过直接分析推断
18835565 MGI
acts upstream of or within actin crosslink formation IMP
IMP: 通过突变表型推断
18835565 MGI
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
23558171 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
33036023 MGI
acts upstream of or within actin filament bundle assembly IMP
IMP: 通过突变表型推断
18264091 MGI
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
28255013 MGI
acts upstream of or within actin filament polymerization IDA
IDA: 通过直接分析推断
23034183 MGI
involved in actin filament polymerization IDA
IDA: 通过直接分析推断
23558171 MGI
acts upstream of or within actin filament polymerization IMP
IMP: 通过突变表型推断
23034183 MGI
acts upstream of or within actin nucleation IDA
IDA: 通过直接分析推断
21278336 MGI
acts upstream of or within autophagosome-lysosome fusion IMP
IMP: 通过突变表型推断
33036023 MGI
acts upstream of or within cell projection organization IDA
IDA: 通过直接分析推断
23441200 MGI
acts upstream of or within chromosome segregation IMP
IMP: 通过突变表型推断
27848932 MGI
acts upstream of or within cytokinesis IDA
IDA: 通过直接分析推断
20660154 MGI
acts upstream of or within cytokinesis IMP
IMP: 通过突变表型推断
24239357 MGI
involved in cytoskeleton organization IDA
IDA: 通过直接分析推断
23558171 MGI
acts upstream of or within endosomal transport IMP
IMP: 通过突变表型推断
33036023 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: 通过突变表型推断
26471482 MGI
acts upstream of or within erythrocyte enucleation IMP
IMP: 通过突变表型推断
18264091 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: 通过突变表型推断
32576838 MGI
acts upstream of or within gene expression IDA
IDA: 通过直接分析推断
21278336 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
32576838 MGI
acts upstream of or within head development IMP
IMP: 通过突变表型推断
27848932 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
24239357 MGI
acts upstream of or within inner ear receptor cell differentiation IDA
IDA: 通过直接分析推断
23441200 MGI
acts upstream of or within integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
32576838 MGI
acts upstream of or within macrophage differentiation IMP
IMP: 通过突变表型推断
26471482 MGI
acts upstream of or within microtubule cytoskeleton organization IDA
IDA: 通过直接分析推断
24069443 MGI
acts upstream of or within microtubule polymerization IDA
IDA: 通过直接分析推断
18458159 MGI
acts upstream of or within microtubule polymerization IMP
IMP: 通过突变表型推断
18458159 MGI
acts upstream of or within negative regulation of microtubule depolymerization IDA
IDA: 通过直接分析推断
18458159 MGI
acts upstream of or within negative regulation of microtubule depolymerization IMP
IMP: 通过突变表型推断
18458159 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
27848932 MGI
acts upstream of or within organelle organization IMP
IMP: 通过突变表型推断
33036023 MGI
acts upstream of or within podosome assembly IMP
IMP: 通过突变表型推断
15976449 MGI
acts upstream of or within protein-containing complex remodeling IMP
IMP: 通过突变表型推断
33036023 MGI
acts upstream of or within regulation of deacetylase activity IDA
IDA: 通过直接分析推断
15976449 MGI
acts upstream of or within sensory perception of sound IDA
IDA: 通过直接分析推断
23441200 MGI
acts upstream of or within spindle checkpoint signaling IMP
IMP: 通过突变表型推断
27848932 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT I complex IMP
IMP: 通过突变表型推断
33036023 MGI
is active in actin filament bundle IDA
IDA: 通过直接分析推断
16556604 MGI
is active in cleavage furrow IDA
IDA: 通过直接分析推断
20660154 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
19117945 MGI
part of filamentous actin IDA
IDA: 通过直接分析推断
18835565 MGI
part of filamentous actin IMP
IMP: 通过突变表型推断
18835565 MGI
is active in microtubule organizing center IDA
IDA: 通过直接分析推断
24069443 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19117945 MGI
is active in ribbon synapse IDA
IDA: 通过直接分析推断
23441200 MGI
is active in spindle pole IDA
IDA: 通过直接分析推断
24069443 MGI
is active in stereocilia tip-link density IDA
IDA: 通过直接分析推断
23441200 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein diaphanous homolog 3

Diaph3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Diaph3 Q9Z207 Abi1 Mus musculus Q8CBW3
Pull Down
18044991
种属内
Diaph3 Q9Z207 Abi1 Mus musculus Q8CBW3
Anti Bait CoIP
18044991
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-168969 AA-BR-157 / 否
HY-RS03765 DIAPH3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21845 Diaph3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Diaph3 NCBI NCBI:81624
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