2. Gene
  3. MAP4K2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

MAP4K2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶激酶 kinase kinase 2

种属: Homo sapiens

同用名: GCK; BL44; RAB8IP

基因 ID: 5871 | 基因类型: protein coding

关于 MAP4K2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,784,918-64,803,214 (from NCBI)

This gene has 13 transcripts (splice variants), 101 orthologues and 35 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 8.4) and 24 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。虽然这种激酶存在于许多组织中，但它在淋巴滤泡中的表达仅限于生发中心的细胞，它可能参与 B 细胞分化。该激酶可被 TNF-α 激活，并已显示可特异性激活 MAP 激酶。还发现该激酶与 TNF 受体相关因子 2 (TRAF2) 相互作用，后者参与 MAP3K1/MEKK1 的激活。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

MAP4K2 基因产物(2)

mRNA Protein Name
NM_001307990.2 NP_001294919.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
NM_004579.5 NP_004570.2 mitogen-activated protein kinase kinase kinase kinase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
11784851 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: 通过物理相互作用推断
17584736 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11784851 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11784851 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11784851 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
17584736 GOA
involved in positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
17584736 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11784851 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP4K2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (16 - 272)

CNH

CNH: CNH domain (492 - 789)

  • 0
  • 200
  • 400
  • 600
  • 820 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 2

B lymphocyte serine/threonine protein kinase

MAPK/ERK kinase kinase kinase 2

MEK kinase kinase 2

MEKKK 2

Rab8 interacting protein

germinal centre kinase (GC kinase)

MAP4K2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP4K2 Q12851 MAP3K1 Homo sapiens Q13233
Anti Bait CoIP
11784851
种属内
MAP4K2 Q12851 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAP4K2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76946 MAP4K2 Protein, Human (sf9, His-GST) Q12851-2 (M1-Y812) ≥95%

关联疾病

疾病名称 别名
Acute Kidney Failure

Acute Renal Failure

Renal Failure Acute

Acute Kidney Injury

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Cavernous Angioma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15434 NG25 Inhibitor 99.35% 否
HY-148063 DB0614 98.80% 否
HY-123714 TL4-12 99.82% 否
HY-77251 TAK1/MAP4K2 inhibitor 1 Inhibitor 99.90% 否
HY-148061 DB1113 99.28% 否
HY-148065 FMF-06-098-1 Inhibitor 98.77% 否
HY-15434A NG25 trihydrochloride Inhibitor / 否
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08076 Map4k2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MAP4K2 VGNC VGNC:81465
Felis catus MAP4K2 VGNC VGNC:82021
Bos taurus MAP4K2 VGNC VGNC:31205
Canis familiaris MAP4K2 VGNC VGNC:42982
Mus musculus MAP4K2 MGD MGI:1346883
Rattus norvegicus MAP4K2 RGD RGD:1308199
Others MAP4K2 NCBI
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