1. Gene
  2. RFX4 - regulatory factor X4 Gene

RFX4 - regulatory factor X4 Gene

中文名称:调节因子 X4

种属: Homo sapiens

同用名: NYD-SP10

基因 ID: 5992 | 基因类型: protein coding

关于 RFX4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,583,004-106,762,803 (from NCBI)

This gene has 12 transcripts (splice variants), 204 orthologues and 7 paralogues. Restricted expression toward testis (RPKM 40.0).

功能概要

该基因是调节因子 X 基因家族的成员,它编码的转录因子包含一个高度保守的有翼螺旋 DNA 结合域。该基因编码的蛋白质在结构上与调节因子 X1、X2、X3 和 X5 相关。它已被证明与自身以及与调节因子 X2 和 X3 相互作用,但它不与调节因子 X1 相互作用。可变剪接导致多个转录本变体。[RefSeq 提供,2011 年 5 月]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

RFX4 基因产物(3)

mRNA Protein Name
NM_001206691.2 NP_001193620.1 transcription factor RFX4 isoform d
NM_032491.6 NP_115880.2 transcription factor RFX4 isoform a
NM_213594.3 NP_998759.1 transcription factor RFX4 isoform c
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16893423 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16893423 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22458338 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16893423 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RFX4 蛋白结构

RFX_DNA_binding

RFX_DNA_binding: RFX DNA-binding domain (60 - 137)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
蛋白主名 其他名称

transcription factor RFX4

regulatory factor X, 4 (influences HLA class II expression)

RFX4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
RFX4 Q33E94 tax Human T-cell leukemia virus 1 P14079 22458338
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Joubert Syndrome 16

JBTS16

Joubert Syndrome, Type 16

Melanotic Medulloblastoma

Medulloblastoma, Melanotic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RFX4 VGNC VGNC:69306
Macaca mulatta RFX4 VGNC VGNC:76909
Bos taurus RFX4 VGNC VGNC:33896
Mus musculus RFX4 MGD MGI:1918387
Canis familiaris RFX4 VGNC VGNC:45506
Rattus norvegicus RFX4 RGD RGD:1562092