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  2. RORB - RAR related orphan receptor B Gene

RORB - RAR related orphan receptor B Gene

中文名称:RAR 相关孤儿受体 B

种属: Homo sapiens

同用名: RZRB; EIG15; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1

基因 ID: 6096 | 基因类型: protein coding

关于 RORB

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:74,497,335-74,693,177 (from NCBI)

This gene has 2 transcripts (splice variants), 398 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.4), endometrium (RPKM 3.4) and 9 other tissues.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它是一种 DNA 结合蛋白,可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合,以增强这些基因的表达。编码的蛋白质已被证明与 NM23-2 相互作用,NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶,并有助于调节一些与昼夜节律有关的基因的表达。[RefSeq 提供,2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RORB 基因产物(2)

mRNA Protein Name
NM_006914.4 NP_008845.2 nuclear receptor ROR-beta isoform 1
NM_001365023.1 NP_001351952.1 nuclear receptor ROR-beta isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23555304 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleoplasm IDA
IDA: 通过直接分析推断
27352968 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RORB 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (20 - 88)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (255 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 470 a.a.
蛋白主名 其他名称

nuclear receptor ROR-beta

RAR-related orphan receptor beta

nuclear receptor RZR-beta

nuclear receptor subfamily 1 group F member 2

retinoic acid-binding receptor beta

retinoid-related orphan receptor beta

RORB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
RORB Q92753 Clock Mus musculus O08785 23555304
种属间
RORB Q92753 Clock Mus musculus O08785
Y2H
23555304
种属间: 跨种属相互作用 种属内: 同种属相互作用

RORB 抗体

目录号 产品名 应用 反应物种
HY-P82662 RORB Antibody (YA2407) WB Human, Mouse

关联疾病

疾病名称 别名
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy

Generalised Epilepsy

Epilepsy, Generalized

EIG

Ige

Epilepsy, Idiopathic Generalized, Susceptibility To, 1

Epilepsy, Idiopathic Generalized 1

Epilepsy, Idiopathic Generalized, Susceptibility To

Epilepsy, Idiopathic, Generalized

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Photosensitive Epilepsy

Pse

Photogenic Epilepsy

Photoparoxysmal Response

Reflex Epilepsy, Photosensitive

Photoparoxysmal Response 1

Retinal Degeneration

Degeneration Of Retina

Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Epilepsy, Childhood Absence 1

Epilepsy, Childhood Absence, Susceptibility To, 1

Epilepsy, Childhood Absence, 1

ECA1

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Epilepsy, Idiopathic Generalized 15

EIG15

Epilepsy, Idiopathic Generalized, Susceptibility To, 15

Idiopathic Generalized Epilepsy 15

{Epilepsy, Idiopathic Generalized, Susceptibility To, 15}

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RORB MGD MGI:1343464
Canis familiaris RORB VGNC VGNC:45696
Rattus norvegicus RORB RGD RGD:1306778
Bos taurus RORB VGNC VGNC:34089
Macaca mulatta RORB VGNC VGNC:76718
Felis catus RORB VGNC VGNC:64722