RORB - RAR related orphan receptor B Gene

中文名称：RAR 相关孤儿受体 B

种属: Homo sapiens

同用名: RZRB; EIG15; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1

基因 ID: 6096 | 基因类型: protein coding

关于 RORB

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:74,497,335-74,693,177 (from NCBI)

This gene has 2 transcripts (splice variants), 398 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.4), endometrium (RPKM 3.4) and 9 other tissues.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它是一种 DNA 结合蛋白，可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已被证明与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，并有助于调节一些与昼夜节律有关的基因的表达。[RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RORB 基因产物(2)

mRNA	Protein	Name
NM_006914.4	NP_008845.2	nuclear receptor ROR-beta isoform 1
NM_001365023.1	NP_001351952.1	nuclear receptor ROR-beta isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23555304	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleoplasm	IDA IDA: 通过直接分析推断	27352968	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RORB 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
470 a.a.

蛋白主名

其他名称

nuclear receptor ROR-beta

RAR-related orphan receptor beta	nuclear receptor RZR-beta
nuclear receptor subfamily 1 group F member 2	retinoic acid-binding receptor beta
retinoid-related orphan receptor beta

RORB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	RORB	Q92753	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304
种属间	RORB	Q92753	Clock	Mus musculus	O08785	Y2H	23555304

种属间: 跨种属相互作用 种属内: 同种属相互作用

RORB 抗体

目录号	产品名	应用	反应物种
HY-P82662	RORB Antibody (YA2407)	WB	Human, Mouse

关联疾病

疾病名称

别名

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Photosensitive Epilepsy

Pse	Photogenic Epilepsy
Photoparoxysmal Response	Reflex Epilepsy, Photosensitive
Photoparoxysmal Response 1

Retinal Degeneration

Degeneration Of Retina

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Epilepsy, Childhood Absence 1

Epilepsy, Childhood Absence, Susceptibility To, 1	Epilepsy, Childhood Absence, 1
ECA1

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Epilepsy, Idiopathic Generalized 15

EIG15	Epilepsy, Idiopathic Generalized, Susceptibility To, 15
Idiopathic Generalized Epilepsy 15	{Epilepsy, Idiopathic Generalized, Susceptibility To, 15}

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12129	RORB Human Pre-designed siRNA Set A		/	否
HY-RS12130	Rorb Mouse Pre-designed siRNA Set A		/	否
HY-RS12131	Rorb Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RORB	MGD	MGI:1343464
Canis familiaris	RORB	VGNC	VGNC:45696
Rattus norvegicus	RORB	RGD	RGD:1306778
Bos taurus	RORB	VGNC	VGNC:34089
Macaca mulatta	RORB	VGNC	VGNC:76718
Felis catus	RORB	VGNC	VGNC:64722

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RORB - RAR related orphan receptor B Gene

关于 RORB

功能概要

RORB 基因产物(2)

RORB 蛋白结构

RORB 蛋白互作信息

RORB 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

RORB - RAR related orphan receptor B Gene

关于 RORB

功能概要

RORB 基因产物(2)

RORB 蛋白结构

RORB 蛋白互作信息

RORB 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z