2. Gene
  3. SEC14L1 - SEC14 like lipid binding 1 Gene

SEC14L1 - SEC14 like lipid binding 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC14 类脂质结合 1

种属: Homo sapiens

同用名: SEC14L; PRELID4A

基因 ID: 6397 | 基因类型: protein coding

关于 SEC14L1

Cytogenetic location: 17q25.2-q25.3 Genomic coordinates (GRCh38): 17:77,088,685-77,217,101 (from NCBI)

This gene has 23 transcripts (splice variants), 213 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 29.8), testis (RPKM 26.1) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 SEC14 细胞溶质因子家族。它与酵母 SEC14 和日本飞乌贼 RALBP 相似，这表明该基因产物可能在细胞内运输系统中发挥作用。已发现该基因的多个选择性剪接转录变体；一些变体代表通读转录本，其中包括来自上游基因 C17orf86 的外显子。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

SEC14L1 基因产物(7)

mRNA Protein Name
NM_001039573.3 NP_001034662.3 SEC14-like protein 1 isoform b
NM_001143998.2 NP_001137470.2 SEC14-like protein 1 isoform a
NM_001143999.2 NP_001137471.2 SEC14-like protein 1 isoform a
NM_001144001.2 NP_001137473.2 SEC14-like protein 1 isoform c
NM_001204408.2 NP_001191337.2 SEC14-like protein 1 isoform b
NM_001204410.2 NP_001191339.2 SEC14-like protein 1 isoform a
NM_003003.4 NP_002994.4 SEC14-like protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RIG-I binding IPI
IPI: 通过物理相互作用推断
23843640 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17092608 GOA
enables protein sequestering activity IDA
IDA: 通过直接分析推断
23843640 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in choline transport IDA
IDA: 通过直接分析推断
17092608 GOA
involved in negative regulation of RIG-I signaling pathway IMP
IMP: 通过突变表型推断
23843640 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with Golgi apparatus IDA
IDA: 通过直接分析推断
17092608 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
23843640 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17092608 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC14L1 蛋白结构

PRELI

PRELI: PRELI-like family (17 - 173)

CRAL_TRIO_N

CRAL_TRIO_N: CRAL/TRIO, N-terminal domain (259 - 296)

CRAL_TRIO

CRAL_TRIO: CRAL/TRIO domain (323 - 490)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
蛋白主名 其他名称

SEC14-like protein 1

SEC14L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SEC14L1 Q92503 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
种属内
SEC14L1 Q92503 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Complement Component 7 Deficiency

C7 Deficiency

C7D
Tylosis With Esophageal Cancer

Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome

TOC

Keratosis Palmaris Et Plantaris With Esophageal Cancer

Bennion-Patterson Syndrome

Howell-Evans Syndrome

Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome

Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome

Tylosis-Oesophageal Carcinoma Syndrome

Palmoplantar Keratoderma With Esophageal Cancer

Howel-Evans Syndrome

Keratosis Palmoplantaris With Esophageal Cancer

Tylosis - Oesophageal Carcinoma

Howel-Evans' Syndrome
Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia
Amyotrophic Neuralgia

Neuralgic Amyotrophy

Brachial Plexus Neuritis

Neuralgic Shoulder Amyotrophy

Acute Brachial Plexus Neuritis

Immune Brachial Plexus Neuropathy

Mononeuritis Multiplex With Brachial Predilection

Parsonage-Turner Syndrome
Brachial Plexus Neuropathy

Brachial Plexopathy

Brachial Plexus Neuropathies

Brachial Plexus Disorder

Bpn - [Brachial Plexus Neuropathy]

Brachial Plexus Disease

Neuropathic Plexus Brachialis

Brachial Plexus Syndrome

Brachial Plexus Irritation

Brachial Plexus Lesion

Brachial Plexus Pressure

Compression Of Brachial Plexus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12606 SEC14L1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SEC14L1 VGNC VGNC:64961
Bos taurus SEC14L1 VGNC VGNC:34404
Mus musculus SEC14L1 MGD MGI:1921386
Macaca mulatta SEC14L1 VGNC VGNC:99226
Rattus norvegicus SEC14L1 RGD RGD:1563123
Canis familiaris SEC14L1 VGNC VGNC:45963
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