2. Gene
  3. SLIT1 - slit guidance ligand 1 Gene

SLIT1 - slit guidance ligand 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：狭缝引导配体 1

种属: Homo sapiens

同用名: MEGF4; SLIL1; SLIT3; SLIT-1

基因 ID: 6585 | 基因类型: protein coding

关于 SLIT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:96,998,038-97,185,959 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues and 25 paralogues. Biased expression in brain (RPKM 15.8) and thyroid (RPKM 1.3).

功能概要

启用 Roundabout 绑定活动。参与轴突延伸参与轴突引导；运动神经元轴突导向；和负趋化性。预测位于细胞外区域。预计在细胞外空间活跃。 [由基因组资源联盟提供，2022 年 4 月]

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SLIT1 基因产物(1)

mRNA Protein Name
NM_003061.3 NP_003052.2 slit homolog 1 protein precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Roundabout binding IPI
IPI: 通过物理相互作用推断
15207848 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21653829 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon extension involved in axon guidance IDA
IDA: 通过直接分析推断
16840550 GOA
involved in axon guidance IDA
IDA: 通过直接分析推断
11748139 GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
IDA: 通过直接分析推断
11748139 GOA
involved in motor neuron axon guidance IMP
IMP: 通过突变表型推断
16162649 GOA
involved in negative chemotaxis IDA
IDA: 通过直接分析推断
11748139 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLIT1 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 60)

LRR_8

LRR_8: Leucine rich repeat (62 - 121)

LRR_8

LRR_8: Leucine rich repeat (159 - 217)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (239 - 264)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (282 - 308)

LRR_8

LRR_8: Leucine rich repeat (334 - 393)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (464 - 488)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (513 - 539)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (544 - 581)

LRR_8

LRR_8: Leucine rich repeat (590 - 649)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (695 - 720)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (733 - 760)

LRR_8

LRR_8: Leucine rich repeat (786 - 844)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (891 - 915)

EGF

EGF: EGF-like domain (929 - 959)

EGF

EGF: EGF-like domain (1047 - 1079)

EGF

EGF: EGF-like domain (1087 - 1116)

Laminin_G_2

Laminin_G_2: Laminin G domain (1195 - 1322)

hEGF

hEGF: Human growth factor-like EGF (1400 - 1412)

hEGF

hEGF: Human growth factor-like EGF (1442 - 1453)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1534 a.a.
蛋白主名 其他名称

slit homolog 1 protein

multiple EGF-like domains protein 4

SLIT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
种属内
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
种属内
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
种属内
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Y2H Array
32296183
种属内
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Validated Y2H
32296183
种属内
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
种属内
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
种属内
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
种属内
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Validated Y2H
32296183
种属内
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Y2H Array
32296183
种属内
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
SLIT1 O75093 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
SLIT1 O75093 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
种属内
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
种属内
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
种属内
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
种属内
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
种属内
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Array
32296183
种属内
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
种属内
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
种属内
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
种属内
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma
Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21757 Slit1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28275 Slit1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLIT1 VGNC VGNC:55971
Felis catus SLIT1 VGNC VGNC:107071
Rattus norvegicus SLIT1 RGD RGD:69307
Macaca mulatta SLIT1 VGNC VGNC:77643
Canis familiaris SLIT1 VGNC VGNC:53014
Mus musculus SLIT1 MGD MGI:1315203
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