CAPN5 - calpain 5 Gene

中文名称：钙蛋白酶 5

种属: Homo sapiens

同用名: VRNI; ADNIV; HTRA3; nCL-3

基因 ID: 726 | 基因类型: protein coding

关于 CAPN5

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:77,066,971-77,126,155 (from NCBI)

This gene has 8 transcripts (splice variants), 286 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 33.5), duodenum (RPKM 28.3) and 19 other tissues.

功能概要

钙蛋白酶是钙依赖性半胱氨酸蛋白酶，参与多种细胞过程中的信号转导。功能性钙蛋白酶由一个不变的小亚基和一个大亚基家族中的一个组成。 CAPN5 是大亚基之一。与某些钙蛋白酶不同，CAPN5 和 CAPN6 缺少类钙调蛋白结构域 IV。由于与秀丽隐杆线虫性别决定基因 tra-3 的显着相似性，CAPN5 也被称为 HTRA3。[RefSeq 提供，2008 年 7 月]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

CAPN5 基因产物(1)

mRNA	Protein	Name
NM_004055.5	NP_004046.2	calpain-5

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	23055945	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAPN5 蛋白结构

Peptidase_C2

Calpain_III

0
100
200
300
400
500
600
640 a.a.

蛋白主名

其他名称

calpain-5

calpain htra-3

CAPN5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CAPN5	O15484	STIP1	Homo sapiens	P31948	Anti Tag CoIP	33961781
种属内	CAPN5	O15484	STIP1	Homo sapiens	P31948	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Vitreoretinopathy, Neovascular Inflammatory

Proliferative Vitreoretinopathy	Adniv
Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy	VRNI
Pvr	Neovascular Inflammatory Vitreoretinopathy
Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant	Retinitis Proliferans
Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant	Vitreoretinopathy Proliferative
Vitreoretinopathy, Proliferative	Proliferative Vitreo-Retinopathy

Vitreoretinopathy

Uveitis

Posterior Uveitis

Uveitis, Posterior	Choroiditis
Uveitis Posterior

Vitreous Disease

Disorder Of Vitreous Body

Macular Dystrophy, Dominant Cystoid

Cystoid Macular Edema	DCMD
Cystoid Macular Dystrophy	Macular Edema, Cystoid
Autosomal Dominant Cystoid Macular Edema	Cymd
Mddc	Familial Macular Edema
Macular Edema	Macular Retinal Edema

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Neovascular Glaucoma

Glaucoma, Neovascular	Secondary Angle-Closure Glaucoma With Rubeosis
Glaucoma Neovascular

Vitreoretinal Dystrophy

Vitreoretinal Dystrophies

Neuroretinitis

Juxtapapillary Focal Retinitis And Retinochoroiditis	Retinitis
Focal Retinitis And Retinochoroiditis, Juxtapapillary	Papilloretinitis

Autoimmune Disease Of Eyes, Ear, Nose And Throat

Autoimmune Uveitis

Retinal Degeneration

Degeneration Of Retina

Retinal Perforation

Retinal Break	Retinal Perforations
Retinal Dialysis	Retinal Tear
Retinal Break Nos	Ruptured Retina

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01891	CAPN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20869	Capn5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27386	Capn5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CAPN5	VGNC	VGNC:38705
Macaca mulatta	CAPN5	VGNC	VGNC:70534
Bos taurus	CAPN5	VGNC	VGNC:26748
Felis catus	CAPN5	VGNC	VGNC:60355
Rattus norvegicus	CAPN5	RGD	RGD:620084
Mus musculus	CAPN5	MGD	MGI:1100859

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CAPN5 - calpain 5 Gene

关于 CAPN5

功能概要

CAPN5 基因产物(1)

CAPN5 蛋白结构

CAPN5 蛋白互作信息

关联疾病

直系同源

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CAPN5 - calpain 5 Gene

关于 CAPN5

功能概要

CAPN5 基因产物(1)

CAPN5 蛋白结构

CAPN5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z