UBP1 - upstream binding protein 1 Gene

中文名称：上游结合蛋白 1

种属: Homo sapiens

同用名: LBP1A; LBP1B; LBP-1B; LBP-1a

基因 ID: 7342 | 基因类型: protein coding

关于 UBP1

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,388,336-33,441,399 (from NCBI)

This gene has 13 transcripts (splice variants), 214 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 21.9), appendix (RPKM 18.6) and 25 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与病毒转录的负调控和 RNA 聚合酶 II 的转录正调控。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

UBP1 基因产物(3)

mRNA	Protein	Name
NM_001128160.2	NP_001121632.1	upstream-binding protein 1 isoform LBP-1a
NM_001128161.2	NP_001121633.1	upstream-binding protein 1 isoform LBP-1b
NM_014517.5	NP_055332.3	upstream-binding protein 1 isoform LBP-1b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	8114710	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	8114710	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20211142	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of viral transcription	IDA IDA: 通过直接分析推断	8114710	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8114710	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10644752	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	8114710	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBP1 蛋白结构

CP2

0
100
200
300
400
500
540 a.a.

蛋白主名

其他名称

upstream-binding protein 1

transcription factor LBP-1

UBP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBP1	Q9NZI7	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
种属内	UBP1	Q9NZI7	TFCP2	Homo sapiens	Q12800	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency	IMD38
Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 38
Isg15 Deficiency, Autosomal Recessive	Immunodeficiency 38, With Basal Ganglia Calcification
Autosomal Recessive Isg15 Deficiency	Msmd Due To Complete Isg15 Deficiency
Immunodeficiency, Type 38

Mixed Glioma

Mixed Gliomas	Mixed Neuroglial Tumor
Glioma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15382	UBP1 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	UBP1	VGNC	VGNC:82712
Mus musculus	UBP1	MGD	MGI:104889
Rattus norvegicus	UBP1	RGD	RGD:1564700
Bos taurus	UBP1	VGNC	VGNC:49155
Canis familiaris	UBP1	VGNC	VGNC:52909
Felis catus	UBP1	VGNC	VGNC:102861
Others	UBP1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBP1 - upstream binding protein 1 Gene

关于 UBP1

功能概要

UBP1 基因产物(3)

UBP1 蛋白结构

UBP1 蛋白互作信息

关联疾病

直系同源

热门区域

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UBP1 - upstream binding protein 1 Gene

关于 UBP1

功能概要

UBP1 基因产物(3)

UBP1 蛋白结构

UBP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z