2. Gene
  3. CCDC6 - coiled-coil domain containing 6 Gene

CCDC6 - coiled-coil domain containing 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含卷曲螺旋结构域 6

种属: Homo sapiens

同用名: H4; PTC; TPC; PTC1; TST1; D10S170

基因 ID: 8030 | 基因类型: protein coding

关于 CCDC6

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:59,788,747-59,906,556 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and is associated with 78 phenotypes. Ubiquitous expression in esophagus (RPKM 21.3), brain (RPKM 15.5) and 25 other tissues.

功能概要

该基因编码含有卷曲螺旋结构域的蛋白质。所编码的蛋白质普遍表达，可能起到肿瘤抑制因子的作用。导致包含该基因的一部分和 RET 原癌基因的细胞内激酶编码域的融合基因表达的染色体重排是甲状腺乳头状癌的原因。[RefSeq 提供，2010 年 9 月]

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the RET proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6 基因产物(1)

mRNA Protein Name
NM_005436.5 NP_005427.2 coiled-coil domain-containing protein 6

CCDC6 蛋白结构

DUF2046

DUF2046: Uncharacterized conserved protein H4 (DUF2046) (2 - 341)

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  • 474 a.a.
蛋白主名 其他名称

coiled-coil domain-containing protein 6

papillary thyroid carcinoma-encoded protein

关联疾病

疾病名称 别名
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary
Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre
Internal Hordeolum
Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b

MEN2B

Wagenmann-Froboese Syndrome

Multiple Endocrine Neoplasia Iib

Mucosal Neuroma Syndrome

Multiple Endocrine Neoplasia, Type 3

Multiple Endocrine Neoplasia, Type 2b

Men Iib

Neuromata, Mucosal, With Endocrine Tumors

Multiple Endocrine Neoplasia, Type Iii, Formerly

Men3, Formerly

Men Type Iib

Men 2b

Multiple Endocrine Neoplasia Type 3

Multiple Neoplasia 2b

Neoplasia, Endocrine, Multiple, Type Iib
Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma

Medullary Carcinoma Of The Thyroid Gland

Ultimobranchial Thyroid Tumor

Ultimobranchial Thyroid Tumour

Thyroid Cancer, Medullary
Commensal Bacterial Infectious Disease
Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-112301 Pralsetinib Inhibitor 99.98% 是
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133551 WF-47-JS03 Inhibitor 99.63% 否
HY-144131 RET-IN-11 / 否
HY-146710 RET-IN-16 Inhibitor / 否
HY-153676 RET-IN-23 Inhibitor / 否
HY-RS02051 CCDC6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CCDC6 MGD MGI:1923801
Canis familiaris CCDC6 VGNC VGNC:38845
Rattus norvegicus CCDC6 RGD RGD:1587433
Bos taurus CCDC6 VGNC VGNC:26904
Macaca mulatta CCDC6 VGNC VGNC:70825
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