2. Gene
  3. Dbn1 - drebrin 1 Gene

Dbn1 - drebrin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 81653 | 基因类型: protein coding

关于 Dbn1

功能概要

Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including positive regulation of cell development; regulation of nervous system process; and regulation of organelle organization. Located in several cellular components, including axon; dendrite; and lamellipodium. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic membrane. Colocalizes with actin filament. Biomarker of Parkinson's disease; cognitive disorder; sciatic neuropathy; temporal lobe epilepsy; and transient cerebral ischemia. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dbn1 基因产物(1)

mRNA Protein Name
NM_031024.2 NP_112286.1 drebrin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
17543276 RGD
enables cytoskeletal motor inhibitor activity IDA
IDA: 通过直接分析推断
17543276 RGD
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
22319661 RGD
enables profilin binding IDA
IDA: 通过直接分析推断
9473484 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16025302 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to X-ray IEP
IEP: 通过表达模式推断
23578130 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
22319661 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
22319661 RGD
involved in lung alveolus development IEP
IEP: 通过表达模式推断
15928322 RGD
involved in modulation of inhibitory postsynaptic potential IMP
IMP: 通过突变表型推断
19174472 RGD
involved in negative regulation of actin filament bundle assembly IDA
IDA: 通过直接分析推断
8769857 RGD
involved in negative regulation of locomotion involved in locomotory behavior IMP
IMP: 通过突变表型推断
15140563 RGD
involved in negative regulation of muscle filament sliding IDA
IDA: 通过直接分析推断
17543276 RGD
involved in nervous system development IEP
IEP: 通过表达模式推断
1611026 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
19222710 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
7478237 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
19174472 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
19174472 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
19222710 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
10320758 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
7478237 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: 通过直接分析推断
12878700 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: 通过突变表型推断
12878700 RGD
involved in prepulse inhibition IMP
IMP: 通过突变表型推断
15140563 RGD
involved in regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
19222710 RGD
involved in regulation of filopodium assembly IMP
IMP: 通过突变表型推断
12878700 RGD
involved in regulation of postsynaptic density protein 95 clustering IMP
IMP: 通过突变表型推断
12878700 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
21262320 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
14623141 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
22319661 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IDA
IDA: 通过直接分析推断
10234022 RGD
located in asymmetric synapse IDA
IDA: 通过直接分析推断
15700273 RGD
located in axonal growth cone IDA
IDA: 通过直接分析推断
19222710 RGD
located in axonal spine IDA
IDA: 通过直接分析推断
15700273 RGD
located in cell-cell junction IDA
IDA: 通过直接分析推断
22319661 RGD
located in dendritic filopodium IDA
IDA: 通过直接分析推断
12878700 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
12878700 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
12878700 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
15700273 RGD
located in filopodium IDA
IDA: 通过直接分析推断
19222710 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8929425 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
12878700 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
19222710 RGD
located in neuron spine IDA
IDA: 通过直接分析推断
10234022 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
18304746 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22319661 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
8929425 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
15700273 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
19539702 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

drebrin

developmentally-regulated brain protein

drebrin E

Dbn1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dbn1 Q07266 Pten Rattus norvegicus O54857
Anti Bait CoIP
23940795
种属内
Dbn1 Q07266 Zmynd8 Rattus norvegicus A8C4G9
IF
24117785
种属内
Dbn1 Q07266 Zmynd8 Rattus norvegicus A8C4G9
Y2H
24117785
种属内
Dbn1 Q07266 Zmynd8 Rattus norvegicus A8C4G9
Pull Down
24117785
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03548 DBN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21320 Dbn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27839 Dbn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dbn1 NCBI NCBI:1627
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