2. Gene
  3. Kcnma1 - potassium calcium-activated channel subfamily M alpha 1 Gene

Kcnma1 - potassium calcium-activated channel subfamily M alpha 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Slo; BKCa; cbv1; slo1; Kcnma; maxiK; KCa1.1; KCNMA1b; KCNMA1c; slo-alpha; BKCA alpha; k(VCA)alpha

基因 ID: 83731 | 基因类型: protein coding

关于 Kcnma1

功能概要

Enables identical protein binding activity; large conductance calcium-activated Potassium Channel activity; and ligand-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and presynaptic active zone membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnma1 基因产物(4)

mRNA Protein Name
NM_001393699.1 NP_001380628.1 calcium-activated potassium channel subunit alpha-1 isoform 2
NM_001393700.1 NP_001380629.1 calcium-activated potassium channel subunit alpha-1 isoform 3
NM_001393701.1 NP_001380630.1 calcium-activated potassium channel subunit alpha-1 isoform 4
NM_031828.2 NP_114016.2 calcium-activated potassium channel subunit alpha-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-activated potassium channel activity IDA
IDA: 通过直接分析推断
9403560 RGD
enables calcium-activated potassium channel activity IMP
IMP: 通过突变表型推断
16166559 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16045448 RGD
enables large conductance calcium-activated potassium channel activity IDA
IDA: 通过直接分析推断
17068255 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential EXP
EXP: 通过实验结果推断
11739569 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
11739569 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16045448 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15141163 RGD
enables voltage-gated potassium channel activity IDA
IDA: 通过直接分析推断
9403560 RGD
enables voltage-gated potassium channel activity IMP
IMP: 通过突变表型推断
16166559 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blood vessel diameter maintenance IDA
IDA: 通过直接分析推断
11157674 RGD
involved in negative regulation of small intestine smooth muscle contraction IMP
IMP: 通过突变表型推断
23647678 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
23653329 RGD
involved in response to calcium ion IDA
IDA: 通过直接分析推断
15111404 RGD
involved in response to estrogen IDA
IDA: 通过直接分析推断
16102753 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
15528406 RGD
involved in response to pH IDA
IDA: 通过直接分析推断
12719228 RGD
involved in vasodilation IMP
IMP: 通过突变表型推断
23432816 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
16045448 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16045448 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
11739569 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11739569 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16045448 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10384881 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
11739569 RGD
located in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
11739569 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17068255 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calcium-activated potassium channel subunit alpha-1

BK channel

calcium-activated potassium channel alpha subunit

calcium-activated potassium channel, subfamily M subunit alpha-1

maxi K channel

potassium channel, calcium activated large conductance subfamily M alpha, member 1

potassium large conductanc

Kcnma1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Kcnma1 Q62976 Mbp Rattus norvegicus P02688
IF
17610306
种属内
Kcnma1 Q62976 Mbp Rattus norvegicus P02688
Pull Down
17610306
种属内
Kcnma1 Q62976 Mbp Rattus norvegicus P02688
Anti Bait CoIP
17610306
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07164 KCNMA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20560 Kcnma1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27069 Kcnma1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kcnma1 NCBI NCBI:3778
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