NUP153 - nucleoporin 153 Gene

中文名称：核孔蛋白 153

种属: Homo sapiens

同用名: N153; HNUP153

关于 NUP153

功能概要

核孔复合物调节大分子在细胞核和细胞质之间的运输。它们由至少 100 个不同的多肽亚基组成，其中许多属于核孔蛋白家族。核孔蛋白是在核孔中发现的糖蛋白，含有特征性五肽 XFXFG 重复序列以及面向细胞质的 O-连接 N-乙酰葡糖胺残基。由该基因编码的蛋白质具有三个不同的结构域：包含孔靶向和 RNA 结合结构域的 N 末端区域、包含多个锌指基序的中心区域和包含多个 XFXFG 重复序列的 C 末端区域。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 5 月]

Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]