2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. YM-1 tosylate

YM-1 tosylate 是稳定的和 MKT-077 类似物和具有口服活性的 Hsp70 抑制剂。YM-1 tosylate 诱导 HeLa 细胞死亡，上调 p53 和 p21 的蛋白水平。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

YM-1 tosylate Chemical Structure

YM-1 tosylate Chemical Structure

CAS No. : 1427450-47-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

YM-1 tosylate 的其他形式现货产品:

Customer Review

Other Forms of YM-1 tosylate:

YM-1 tosylate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM-1 tosylate is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 tosylate induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2].
IC50 & Target[1]

HSP70

3.2 μM (IC50)

体外研究
(In Vitro)

YM-1 tosylate 促进 Nnos 成熟过程中依赖 Hsp70 的步骤，阻断部分与 ATP 的结合[1]。
YM-1 (0-200 μM) tosylate 激活 Hsp70 与未折叠底物的结合[1]。
YM-1 (0.001-1000 μM) tosylate 将 Hsp70 转化为紧密亲和构象，与 Hsp70 结合的 IC50 值为 8.2 μM[1]。
YM-1 (0，0.1，0.5 和 1 μM；24 小时) tosylate 促进 nNOS 泛素化[1]。
YM-1 (5 和 10 μM；24 和 48 小时) tosylate 诱导 HeLa 细胞死亡和 hTERT-RPE1 细胞生长停滞[2]
YM-1 (10 μM；48 小时) tosylate 上调 p53 和 p21，下调 FoxM1 和 survivin 的蛋白水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YM-1 tosylate 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF7, MCF10A and MDA-MB-231
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Inhibited viability with EC50s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM for MDA-MB-231, MCF10A and MCF7, respectively.
体内研究
(In Vivo)

YM-1 (1 mM；口服，持续 7 天) tosylate 通过激活 Hsp70 挽救果蝇中的 polyQ 毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection (Pharmacokinetic Analysis)
Result: Initial pharmacokinetics of HSP70-IN-4 (Compound YM-01; 20 mg/kg; i.v.)[1]
hour plasma (ng/mL) brain (ng/g) kidney (ng/g)
0.16 359 0 74378
1 324 0 63231
Animal Model: UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotype[1]
Dosage: 1 mM
Administration: Oral administration; 1 mM, for 7 days
Result: Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.
分子量

553.72

Formula

C27H27N3O4S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YM-1 tosylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-11427450-47-2YM1YM 1HSPHeat shock proteinsblood-brain barrierBBBMDA-MB-231MCF10AMCF7Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
YM-1 tosylate
目录号：
HY-18406
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z